CN106109951A - Prevent and treat medicine of hyperglycemia, hyperlipidemia, hypertension and preparation method thereof - Google Patents
Prevent and treat medicine of hyperglycemia, hyperlipidemia, hypertension and preparation method thereof Download PDFInfo
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- CN106109951A CN106109951A CN201610541924.1A CN201610541924A CN106109951A CN 106109951 A CN106109951 A CN 106109951A CN 201610541924 A CN201610541924 A CN 201610541924A CN 106109951 A CN106109951 A CN 106109951A
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- extract
- rhizoma coptidis
- panacis quinquefolii
- herba dendrobii
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension and preparation method thereof, being made up of Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, Herba Dendrobii extract, described Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are 16～18: 6～8: 2～4: 2～4.This patent uses Radix Panacis Quinquefolii to have QI invigorating, nourishing YIN, the effect of nourishing the five internal organs, the silt hemostasis of having of Radix Notoginseng, the effect of subduing swelling and relieving pain, Xu-tonic, the merit of hemopoietic of enriching blood, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat and berberine special role in terms of lowering blood pressure and blood fat, blood sugar lowering, carry out scientific compatibility, make each composition play one's part to the full, and mutually promote, obtain that a kind of prevention effect is good, instant effect, the prevention having no side effect and treatment hypertension, hyperlipidemia, the novel drugs of hyperglycemia.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, a kind of medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension
Thing and preparation method thereof.
Background technology
Hyperglycemia, hyperlipidemia, hypertension are commonly called as three-hypers disease.According to relevant medical mechanism clinical studies show, hyperlipidemia
Causing blood vessel scleratheroma, blood vessel scleratheroma and then initiation hypertension, long-term hyperlipidemia can make triglyceride and free-fat
Acid concentration increases and then causes hyperglycemia.
Hypertension early symptom show as headache, dizziness, tinnitus, cardiopalmus, dim eyesight, absent minded, hypomnesis,
The symptoms such as numbness of hands and feet, fatigue and weak, easily agitation.Diabetes are a kind of chronic, lifelong disease, are a kind of serious harm human bodies
Healthy commonly encountered diseases, the symptom of diabetes is " three-many-one-little ", i.e. polyuria, polydipsia, polyphagia and weight loss；Hyperlipidemia refers to blood
Middle cholesterol or triglyceride is too high or HDL-C is too low, easily causes " blood is thick ", deposits in blood vessel wall,
Gradually forming atherosclerosis, gradually block blood vessel, make blood flow slack-off, time serious, blood flow interrupts.This shows, three-hypers disease is serious
Affect the health of the mankind.
Although modern medicine achieves the biggest development, make three-hypers disease obtain effective control, but the thing followed is
Chemical drugs, the toxic and side effects of synthetic drug are on the rise, and iatrogenic disease and drug-induced disease emerge in multitude.According to relevant report
Road, China there are about 19.2 ten thousand people every year and dies from drug-induced disease.For chronic disease this to three-hypers disease, although Drug therapy can
Effectively to control symptom and the state of an illness of disease, but in most cases medicine can only take stopgap measures and is difficult to effect a permanent cure, so three-hypers disease patient
The state of an illness may often be such that and the most constantly increase the weight of, drug use amount is also stepped up, and the toxic and side effects of medicine is very, the most right
Human body each system internal organs produce again more destruction, thus form vicious cycle.
Summary of the invention
It is an object of the invention to provide that a kind of prevention effect is good, have no side effect, after medication internal organs various to human body without shadow
Medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension rung and preparation method thereof, overcomes the deficiencies in the prior art.
The medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension of the present invention, is extracted by Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii
Thing, Herba Dendrobii extract form, and described Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are
16～18: 6～8: 2～4: 2～4.
Described Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are preferably 17: 7: 3
∶3。
The preparation method of the medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension of the present invention, step is as follows:
(1), Radix Notoginseng powder is prepared
Selected Radix Notoginseng, dust removal roguing, micronizing is standby to 200 mesh；
(2), Radix Panacis Quinquefolii extract is prepared
A, Radix Panacis Quinquefolii is put in extraction pot, with the ethanol extraction twice of concentration 75%；
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Panacis Quinquefolii, heats with jacket steam, and steam pressure is
0.1Mpa, heats 30 minutes, and backflow limit, limit is heated, and in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C
Stopping heating, keep in tank 80 DEG C of constant temperature two hours, then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter
140 eye mesh screens filter, and are transported to storage tank with stainless steel pump stand-by；
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Panacis Quinquefolii, after adding ethanol, with extracting for the first time；Two
Secondary ethanol extract merges stand-by；
B, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is entered
Row vacuum drying, makes dry cream moisture ＜ 5%, collects dry cream, pulverizes, and packaging obtains Radix Panacis Quinquefolii extract；
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, take Herba Dendrobii and be crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C,
Each 45 minutes of extraction time, extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder, and second time is extracted pure
Changing water addition is: 8 liters/1 kilogram dendrobium officinale powder, and extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out reducing pressure dense
Contracting, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize, packaging, obtain stone
Dry measure used in former times extract；
(4), Rhizoma Coptidis extract is prepared
Utilize ultrasonic extracting process, take Rhizoma Coptidis powder and be broken to 40 mesh, ultrasonic frequency 50KHz, Extracting temperature 60 DEG C, extract
Each 30 minutes of time, extracting ethanol addition for the first time is: 10 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, second time carries
Taking ethanol addition is: 8 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, and extracting solution is performing centrifugal separation on, and merges twice extracting solution,
Carrying out concentrating under reduced pressure, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize,
Packaging, obtains Rhizoma Coptidis extract；
(5), by Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, Herba Dendrobii extract by 16～18: 6～8: 2～4: 2～
The quality proportioning mix homogeneously of 4 or 17: 7: 3: 3, is prepared as hard capsule or tablet or granule or powder, must prevent and treat hyperglycemia, height
Blood fat, the medicine of hypertension.
In the medicine of the present invention, Radix Notoginseng sweet in the mouth, micro-hardship, warm in nature, return liver, stomach, the heart, small intestine meridian, there is hemostasis, dissipating blood stasis, disappear
Swollen, pain relieving, qi-restoratives, the effect such as strong, cure mainly spitting of blood, epistaxis, traumatic hemorrhage, treating swelling and pain by traumatic injury etc., be used in recent years treating coronary disease
Disease, diabetes, antianginal, antithrombotic etc..Wherein hypoglycemic activity: Radix Notoginseng total arasaponins can substantially increase liver uniform metabolism Fructus Vitis viniferae
Sugar and the oxygen consumption of sodium succinate, promote Mouse Liver Glycogen synthesis, and blood sugar reducing function is that it mainly goes by directly facilitating carbohydrate metabolism
Road is tissue to be realized links such as picked-up, oxidation and the Glycogen synthesis of glucose.Radix Notoginseng can resist thrombin induction from fiber
Proteinogen is to fibrinous conversion, and activates urokinase, promotes fibrinous dissolving, is described as the street cleaner of blood vessel.Fall
Blood fat: Radix Notoginseng total arasaponins has stronger lipoid peroxidization resistant, can significantly reduce blood fat.Hypotensive activity: Radix Notoginseng
Total saponins can suppress calcium ion to make smooth muscle loosening by cardiac muscle and vascular smooth muscle cell film, and peripheral resistance reduces, thus reaches
To blood pressure lowering Antianginal effect.
Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, the double effects that pathogenic fire reducing is relieved summer heat, and Radix Panacis Quinquefolii saponin is
One of topmost effective ingredient in Radix Panacis Quinquefolii, modern study shows that Radix Panacis Quinquefolii has physical strength reinforcing have athlete and greatly helps
Benefit, has Accommodation to blood pressure, makes temporary or persistency blood pressure drops.Suppression arteriosclerosis also promotes Growth of red blood cells, increases
Add the deal of hematochrome, the secretion of islets of langerhans can be regulated, therefore powerful to diabetes.
Herba Dendrobii is exactly legendary " help Herba mesonae chinensis ", because its composition Han several functions makes it have enhancing immunity
The pharmacological actions such as power, antioxidation, blood fat reducing, blood pressure lowering, digestion promoting, antitumor, the most topmost functional component is that Herba Dendrobii is many
Sugar.Wherein effect for reducing blood fat: modern study finds that dendrobium polysaccharide has regulation effect equally to the Developmental and Metabolic Disorder of lipid, has bright
Aobvious Adjust-blood lipid, protection blood vessel endothelium and the effect of anti peroxidation of lipid, has prevention for fatty liver, atherosclerosis etc.
Effect.
Hyperlipidemia is frequently accompanied by the change of Lipid Peroxidation, plays important in atherosclerotic lesion occurs
Effect, Herba Dendrobii can improve the level of lipid peroxidation of body thus suppress atherosclerotic generation and development, and this is also
It is its reason that alcoholic liver injury is played a role in improving, and Herba Dendrobii is by affecting the activity of some enzyme of human body, improve height
The oxidation resistance of blood fat disease body, alleviates lipid peroxidation, plays a protective role cardiovascular system further；Li Yamei etc.
People's research shows that Herba Dendrobii can effectively reduce relevant lipid content in mice serum, reduces the generation of inflammatory reaction, alleviates dynamic
Pulse atherosclerosis damages.
Clinical research shows, Herba Dendrobii can expand blood vessel, effectively facilitates human body to various nutrient substance, vitamin and ore deposit
The absorption of material, improves metabolism, improves the physiological function of each organ of health.To promoting circulation, expansion blood vessel, reduction gallbladder are solid
Alcohol and triglyceride have positive effect.Hypoglycemic activity: Herba Dendrobii replenishing YIN and removing heat is moisturized, treats glycosuria the most exactly
Sick medicine dedicated.Clinical research shows, Herba Dendrobii is possible not only to strengthen insulin active, simultaneously can significant reduction blood glucose water
Flat, make blood glucose normal.
Rhizoma Coptidis is mainly in fall heat analgesia, anti-enterobacterial infection, and modern study finds that Rhizoma Coptidis also has arrhythmia, fall
The pharmacological actions such as blood fat, blood sugar lowering, antiplatelet aggregation.Wherein effect for reducing blood fat: the active component of Rhizoma Coptidis extract is Rhizoma Coptidis
Element, berberine Adjust-blood lipid is by strengthening the expression of low density lipoprotein receptor, adenosine-phosphatase activity protein kinase suppression
The synthesis of lipid, raising lipoprotein lipase activity, the expression of suppression peroxisome proliferators activated receptor γ, suppression fat
The mechanism regulating blood lipid levels such as the differentiation of fat cell and reduction serum free fatty acid, improve hyperlipidemia.Hypoglycemic activity: according to existing
For pharmacology and clinical research confirmation, Rhizoma Coptidis have significant hypoglycemic activity.Berberine can be promoted by suppression glucose absorption
The consumption of glucose and transhipment；Increase insulin sensitivity, improve insulin resistant；Improve the function of islet cells, promote pancreas
Island element secretion number of ways reaches hypoglycemic purpose.Can also be by reducing free fatty Fatty toxicity and tissue triacylglycerol
Deposition, reduces beta Cell of islet damage, improves the function of islets of langerhans, promote insulin secretion, thus reach hypoglycemic purpose.Fall
Blood pressure effect: the hypertension that a variety of causes is caused by berberine all has a better role, it is possible to improve symptom, the diastole of left room
Function, myocardial ischemia, correct blood fat, dysglycemia, reduces blood viscosity.
This patent uses Radix Panacis Quinquefolii to have QI invigorating, nourishing YIN, the effect of nourishing the five internal organs, and the silt of having of Radix Notoginseng is stopped blooding, detumescence is fixed
The effect of pain, Xu-tonic, the merit of hemopoietic of enriching blood, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat and berberine are at blood pressure lowering, fall blood
Special role in terms of fat, blood sugar lowering, carries out scientific compatibility, makes each composition play one's part to the full, and mutually promotes, obtains one
Prevention effect is good, instant effect, the prevention having no side effect and treatment hypertension, hyperlipidemia, the novel drugs of hyperglycemia.
Detailed description of the invention
The medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension of the present invention, is extracted by Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii
Thing, Herba Dendrobii extract form, and described Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are
16 or 17 or 18: 6 or 7 or 8: 2 or 3 or 4: 2 or 3 or 4.
Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are preferably 17: 7: 3: 3.
The preparation method of the medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension of the present invention, step is as follows:
(1), Radix Notoginseng powder is prepared
Selected dry product Radix Notoginseng, dust removal roguing, micronizing to 170 mesh or 200 mesh or 230 mesh are standby (at 170～230 mesh
Between)；
(2), Radix Panacis Quinquefolii extract is prepared
A, two product Radix Panacis Quinquefoliis are put in extraction pot, with the ethanol extraction twice of concentration 75%；
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Panacis Quinquefolii, heats with jacket steam, and steam pressure is
0.1Mpa, heats 30 minutes, and backflow limit, limit is heated, and in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C
Stopping heating, keep in tank 80 DEG C of constant temperature two hours, then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter
140 eye mesh screens filter, and are transported to storage tank with stainless steel pump stand-by；
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Panacis Quinquefolii, after adding ethanol, with extracting for the first time；Two
Secondary ethanol extract merges stand-by；
B, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is entered
Row vacuum drying, makes dry cream moisture ＜ 5%, collects dry cream, pulverizes, and packaging obtains Radix Panacis Quinquefolii extract；
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, take Herba Dendrobii and be crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C,
Each 45 minutes of extraction time, extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder, and second time is extracted pure
Changing water addition is: 8 liters/1 kilogram dendrobium officinale powder, and extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out reducing pressure dense
Contracting, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize, packaging, obtain stone
Dry measure used in former times extract；
(4), Rhizoma Coptidis extract is prepared
Utilize ultrasonic extracting process, take Rhizoma Coptidis powder and be broken to 40 mesh, ultrasonic frequency 50KHz, Extracting temperature 60 DEG C, extract
Each 30 minutes of time, extracting ethanol addition for the first time is: 10 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, second time carries
Taking ethanol addition is: 8 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, and extracting solution is performing centrifugal separation on, and merges twice extracting solution,
Carrying out concentrating under reduced pressure, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize,
Packaging, obtains Rhizoma Coptidis extract；
(5), by Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, Herba Dendrobii extract by 16～18: 6～8: 2～4: 2～
The quality proportioning mix homogeneously of 4 or 17: 7: 3: 3, is prepared as hard capsule or tablet or granule or powder, must prevent and treat hyperglycemia, height
Blood fat, the medicine of hypertension.
Application example:
Mr. Ma, 56 years old, individual operator.In March, 2015, find hypertension symptom have half a year many, companion hectic fever, night sweat,
Insomnia, agitation.Make a definite diagnosis through hospital, hypertension with type ii diabetes and hyperlipidemia.After hospitalize, patient takes for a long time
With blood pressure lowering, hypoglycemic medicine, take regular exercise, state of an illness basic controlling but need Long-term taking medicine, and the side effect of Western medicine is more and more brighter
Aobvious.After taken the medicine of the present invention, after taking two months, eliminate the symptom such as former agitation, dizziness；Within three month, continue
Taking the medicine of the present invention, and reduce the dose of depressor and antidiabetic drug, check after 6 months, blood pressure and blood fat are the most recovered
Normally.
Mrs Duan, nineteen sixty-eight birth, worker, Dalian Zhuanghe people.Patient in August, 2014 do not have inducement occur polydipsia,
Polyphagia, polyuria, xerostomia, and the symptom become thin therewith, after go local hospital to go to a doctor, and be diagnosed as " type ii diabetes ", move in and work as
Leave hospital after ground hospital is stable, take antidiabetic drug by doctor's advice, taken the medicine of the present invention simultaneously, and gradually decreased antidiabetic drug,
Sb.'s illness took a favorable turn for sensation rapidly, eliminates the symptoms such as dizziness.Cut out Western medicine antidiabetic drug at present, adhered to taking this product,
Blood sugar test is stable.
Mr. Qin, life in 1972, profession.Long-term alcohol, smoking, diet is irregular, and with polyphagia, polydipsia, many
The symptoms such as urine, feel that fatigue does not has spirit especially.Within 2014, find to suffer from diabetes, glycemic index 14.2, and with hypertension,
The most uncomfortable in chest, finger is numb.Go examination in hospital blood routine examination, its T-CHOL, low-density lipoprotein cholesterol, triglyceride
Higher, produce serious fatigue syndrome.Change dietary habit, adhere to motion, take the medicine of the present invention in January, 2015, three
After individual month, fatigue conditions be improved significantly；After continuing to take three months, hypertension, hyperlipidemia characterize and substantially eliminate, and blood glucose refers to
Number is stable, and health is good, and adheres to taking this product always.
Claims (3)
1. the medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension, it is characterised in that: by Radix Notoginseng powder, Rhizoma Coptidis extract, the West
Conopsea extraction, Herba Dendrobii extract form, described Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality of Herba Dendrobii extract
Proportioning is 16～18: 6～8: 2～4: 2～4.
The medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension the most according to claim 1, it is characterised in that: described Radix Notoginseng
Powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, the quality proportioning of Herba Dendrobii extract are 17: 7: 3: 3.
3. a preparation method for the medicine preventing and treating hyperglycemia, hyperlipidemia, hypertension according to claim 1 and 2, it is special
Levy and be: step is as follows:
(1), Radix Notoginseng powder is prepared
Selected Radix Notoginseng, dust removal roguing, micronizing is standby to 200 mesh；
(2), Radix Panacis Quinquefolii extract is prepared
A, Radix Panacis Quinquefolii is put in extraction pot, with the ethanol extraction twice of concentration 75%；
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Panacis Quinquefolii, heats with jacket steam, and steam pressure is 0.1Mpa, adds
Heat 30 minutes, the heating of backflow limit, limit, in making tank, temperature is unanimous between the higher and lower levels, when in extraction pot, feed temperature rises to 80 DEG C of stopping heating,
Keeping in tank 80 DEG C of constant temperature two hours, then extracted tank bottoms 120 eye mesh screens of extracting solution filter, then through filter 140 eye mesh screen
Filter, be transported to storage tank with stainless steel pump stand-by；
Ethanol addition is that inventory is for the second time: 6 liters/1 kilogram Radix Panacis Quinquefolii, after adding ethanol, with extracting for the first time；Twice second
Alcohol extract merges stand-by；
B, a walks twice alcohol extract carrying out vacuum-concentrcted, being concentrated into density is 1.20g/cm3, condensed cream is carried out vacuum
It is dried, makes dry cream moisture ＜ 5%, collect dry cream, pulverize, packaging, obtain Radix Panacis Quinquefolii extract；
(3), Herba Dendrobii extract is prepared
Utilize ultrasonic extracting process, take Herba Dendrobii and be crushed to 40 mesh, ultrasonic frequency 60KHz, Extracting temperature 55 DEG C, extract
Each 45 minutes of time, extraction purification water addition is for the first time: 10 liters/1 kilogram dendrobium officinale powder, for the second time extraction purification water
Addition is: 8 liters/1 kilogram dendrobium officinale powder, and extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out concentrating under reduced pressure, dense
Being reduced to density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize, packaging, obtain Herba Dendrobii and extract
Thing；
(4), Rhizoma Coptidis extract is prepared
Utilize ultrasonic extracting process, take Rhizoma Coptidis powder and be broken to 40 mesh, ultrasonic frequency 50KHz, Extracting temperature 60 DEG C, extraction time
Each 30 minutes, extracting ethanol addition for the first time was: 10 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, second time extracts second
Alcohol addition is: 8 liters/1 kilogram Rhizoma Coptidis powder of the ethanol of concentration 60%, extracting solution is performing centrifugal separation on, and merges twice extracting solution, carries out
Concentrating under reduced pressure, being concentrated into density is 1.20g/cm3, condensed cream is vacuum dried, makes dry cream moisture ＜ 5%, pulverize, bag
Dress, obtains Rhizoma Coptidis extract；
(5), by Radix Notoginseng powder, Rhizoma Coptidis extract, Radix Panacis Quinquefolii extract, Herba Dendrobii extract by 16～18: 6～8: 2～4: 2～4 or
The quality proportioning mix homogeneously of 17: 7: 3: 3, is prepared as hard capsule or tablet or granule or powder, must prevent and treat hyperglycemia, high blood
Fat, the medicine of hypertension.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107537028A (en) * | 2017-07-19 | 2018-01-05 | 江苏天美健大自然生物工程有限公司 | A kind of while auxiliary hyperglycemic and the formula of hypotensive and preparation method thereof |
| CN113952417A (en) * | 2021-10-30 | 2022-01-21 | 安徽同济生生物科技有限公司 | Preparation method of dry dendrobium alcohol extract for spontaneous hypertension |
| CN116803396A (en) * | 2023-05-26 | 2023-09-26 | 中国农业大学 | Application of dendrobium polysaccharide in delaying the development of atherosclerosis |
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|---|---|---|---|---|
| CN102100761A (en) * | 2011-01-25 | 2011-06-22 | 广州中医药大学 | Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof |
| CN103285240A (en) * | 2013-03-07 | 2013-09-11 | 上海仙草堂保健食品有限公司 | Dendrobium Panax quinquefolius buccal tablet and its preparation method |
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2016
- 2016-07-11 CN CN201610541924.1A patent/CN106109951A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100761A (en) * | 2011-01-25 | 2011-06-22 | 广州中医药大学 | Plant extract composition for preventing and treating lipidmetabolic disorder and preparation method thereof |
| CN103285240A (en) * | 2013-03-07 | 2013-09-11 | 上海仙草堂保健食品有限公司 | Dendrobium Panax quinquefolius buccal tablet and its preparation method |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107537028A (en) * | 2017-07-19 | 2018-01-05 | 江苏天美健大自然生物工程有限公司 | A kind of while auxiliary hyperglycemic and the formula of hypotensive and preparation method thereof |
| CN113952417A (en) * | 2021-10-30 | 2022-01-21 | 安徽同济生生物科技有限公司 | Preparation method of dry dendrobium alcohol extract for spontaneous hypertension |
| CN116803396A (en) * | 2023-05-26 | 2023-09-26 | 中国农业大学 | Application of dendrobium polysaccharide in delaying the development of atherosclerosis |
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Application publication date: 20161116 |