CN105168555A

CN105168555A - Preparation for treating cerebral cancer and preparation method of preparation

Info

Publication number: CN105168555A
Application number: CN201510625144.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-09-28
Filing date: 2015-09-28
Publication date: 2015-12-23

Abstract

The invention discloses a preparation for treating the cerebral cancer. The preparation is mainly prepared from, by mass, 8-14 parts of selaginella doederleinii hieron, 10-15 parts of hairyvein agrimony, 9-16 parts of crepis phoenix, 7-15 parts of walnut twigs, 6-10 parts of dysosma versipellis, 11-15 parts of corydalis sheareri, 12-20 parts of angelica sinensis, 9-14 parts of eclipta, 11-16 parts of cordyceps sinensis, 8-15 parts of tabernaemontana divaricata, 6-12 parts of gledtsiae semen, 10-17 parts of drum fish, 9-13 parts of kumquat roots, 8-12 parts of morinda officinalis, 9-15 parts of lonicera maackii, 6-14 parts of garden balsam and 11-17 parts of scrophularia ningpoensis. The preparation is prepared through summarization of multiple years of clinical practices, has the effects of detoxification, stasis removal, qi tonifying, spleen tonifying, heat clearing and pain stopping, and is remarkable in curative effect.

Description

For curing preparation and the method for making of the brain cancer

Technical field

The present invention relates to traditional Chinese medicine field, particularly relating to the preparation for curing the brain cancer and method for making.

Background technology

The brain cancer refers to that growth is in the neoplasm of cranial cavity, also known as intracranial tumor, can originate from brain, meninges, nerve, blood vessel and brain adnexa, or is formed by its hetero-organization of health or Organ relative weight Intracranial invasion.Early morning, headache was the early symptom of the common brain cancer, often occurred in four or five o'clock of early morning, was often bitterly waken up in sleeping soundly, and has a headache and alleviate gradually or disappear after gentle activity of getting up.The tumor of the brain cancer of posterior cranial fossa can cause cervical pain and to eye socket radiation, headache degree is aggravated gradually with disease progression.Also can there is visual disorder in the early symptom of the brain cancer, increased intracranial pressure can make eyeball venous return enter brain and freely not cause edema, and cause visual deterioration, person's eye ground that the serious brain cancer is suffered from has point-like, wire, lamellar pathological changes even hemorrhage, blurred vision.The vomiting of brain cancer patient without abdominal distention, nauseating, diarrhoea, but when intracranial pressure increases, there will be " spurting vomiting " symptom after headache.This is also the early symptom performance of the comparatively typical brain cancer.The symptom of the brain cancer depends primarily on two factors: the size (volume) of tumor, the position of tumor.

Publication No. CN104013833A(application number 201410280147.0) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of the brain cancer, described pharmaceutical composition is made with the raw material of following weight parts: Fructus Viticis 12-24 part, Semen Sinapis Albae 12-24 part, Ramulus Uncariae Cum Uncis 12-24 part, Flos Carthami 12-24 part, Rhizoma Chuanxiong 12-24 part, Radix Salviae Miltiorrhizae 12-24 part, Rhizoma Gastrodiae 12-24 part, Radix Polygoni Multiflori 12-24 part, Rhizoma Cimicifugae 12-24 part, Sanguis Draxonis 9-21 part, Scolopendra 9-21 part, Semen Persicae 9-21 part, Squama Manis 9-21 part, Radix Notoginseng 9-21 part, Borneolum Syntheticum 9-21 part, Indigo Naturalis 9-21 part, Calomelas 9-21 part be combined as active component.Publication No. CN104840748A(application number 201510254817.6) Chinese patent literature disclose a kind of have Chinese medicine composition of anti-brain cancer activity and preparation method thereof and its application, this Traditional Chinese medicine compound composition is by Rhizoma Typhonii (processed) 10 ~ 30 parts, Pseudobulbus Cremastrae Seu Pleiones 15 ~ 45 parts, Scolopendra 3 ~ 9 parts, Rhizoma Arisaematis (processed) 10 ~ 30 parts, Herba Lycopi 10 ~ 30 parts, Rhizoma Alismatis 10 ~ 30 parts is made.Publication No. CN103272109A(application number 201310241277.9) Chinese patent literature disclose a kind of medicament for the treatment of the brain cancer, it comprises the material of following weight proportioning: Rhizoma Arisaematis 20-50 part, Radix Gei japonici 50-70 part, Rhizoma Paridis 12-15 part, Fructus Forsythiae 20-25 part, Spica Prunellae 20-30 part, Radix Rehmanniae 20-25 part, Radix Cudraniae 20-25 part, Rhizoma Dioscoreae 15-21 part, Os Draconis 20-25 part, Semen Juglandis 20-30 part and Rhizoma Pinelliae 15-20 part.

Though operative treatment can remove tumor fast, relapse rate is high, and treatment by Chinese herbs to have side effect little, the advantage that anti-recurrence rate is effective, can stablize the state of an illness, indiffusion, part Chinese medicine formula Clinical Practice, therapeutic effect is poor, therefore needs to work out Be very effective, formula that anti-relapse rate is high.

Summary of the invention

For the problem of prior art, the object of this invention is to provide a kind of Be very effective, taking safe and applicable wide preparation and method for making for curing the brain cancer.

Technical scheme of the present invention is:

For curing the preparation of the brain cancer, being prepared from primarily of following bulk drugs, being mass parts: Herba Selaginellae Doederleinii 8-14; Herba Agrimoniae 10-15; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 9-16; Ramulus Juglandis 7-15; Radix et Rhizoma Dysosmatis 6-10; Herba Corydalis tailensis 11-15; Radix Angelicae Sinensis 12-20; Herba Ecliptae 9-14; Cordyceps 11-16; GOUYAHUA 8-15; Semen Gleditsiae 6-12; Carnis Pseudosciaenae 10-17; Radix Fortunellae Margaritae 9-13; Radix Morindae Officinalis 8-12; Flos Lonicerae maackii 9-15; Semen Impatientis 6-14; Radix Scrophulariae 11-17.

Preferred version is, Herba Selaginellae Doederleinii 10-12; Herba Agrimoniae 11-14; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-15; Ramulus Juglandis 9-13; Radix et Rhizoma Dysosmatis 7-9; Herba Corydalis tailensis 12-14; Radix Angelicae Sinensis 14-18; Herba Ecliptae 10-13; Cordyceps 12-15; GOUYAHUA 10-13; Semen Gleditsiae 8-10; Carnis Pseudosciaenae 12-15; Radix Fortunellae Margaritae 10-12; Radix Morindae Officinalis 9-11; Flos Lonicerae maackii 10-14; Semen Impatientis 8-12; Radix Scrophulariae 13-15.

More preferably, Herba Selaginellae Doederleinii 11; Herba Agrimoniae 12.5; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12.5; Ramulus Juglandis 11; Radix et Rhizoma Dysosmatis 8; Herba Corydalis tailensis 13; Radix Angelicae Sinensis 16; Herba Ecliptae 11.5; Cordyceps 13.5; GOUYAHUA 11.5; Semen Gleditsiae 9; Carnis Pseudosciaenae 13.5; Radix Fortunellae Margaritae 11; Radix Morindae Officinalis 10; Flos Lonicerae maackii 12; Semen Impatientis 10; Radix Scrophulariae 14.

The described preparation for curing the brain cancer, be made into pharmaceutically acceptable decoction, its preparation method is:

(1) get Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix et Rhizoma Dysosmatis, Radix Angelicae Sinensis, GOUYAHUA, Radix Fortunellae Margaritae, Radix Morindae Officinalis and Radix Scrophulariae and clean remove impurity, be cut into sheet, be placed in frying pan, slow fire stir-fries to surperficial zoom, and taking-up cools;

(2) Herba Selaginellae Doederleinii, Herba Agrimoniae, Ramulus Juglandis, Herba Corydalis tailensis, Herba Ecliptae and Flos Lonicerae maackii are cleaned, Steam by water bath 10-20 minute (preferred: Steam by water bath 15 minutes), take out, drench into refined honey water, the micro-stir-fry of little fire 6 minutes, taking-up cools;

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, add Cordyceps and Carnis Pseudosciaenae again, decoct with water twice, the 6-9 that each amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality), big fire turns little fire after boiling and decocts, and after filtration, merges twice gained filtrate;

(4) get Semen Gleditsiae and Semen Impatientis to clean, be placed in saline and infiltrate, take out and dry, put into parch container, add edible oil moderate heat fry 6-14 minute (preferred: moderate heat fries 8-12 minute; Be more preferably: moderate heat fries 10 minutes), take out, pulverize;

(5) join in step (3) gained filtrate by step (4) made crude drug, heating is concentrated into the half of original volume, obtains decoction.

The preparation method of the described preparation decoction for curing the brain cancer, step (3) big fire turns little fire and decocts 18-28 minute (preferably: big fire turns a little fire after boiling and decocts 20-26 minute after boiling; Be more preferably: big fire turns little fire after boiling and decocts 23 minutes).

The described preparation for curing the brain cancer, be made into pharmaceutically acceptable honeyed pill, its preparation method is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, add Cordyceps and Carnis Pseudosciaenae again, add boiled crude drug quality 6-8 water doubly (preferred: the water adding boiled crude drug quality 7 times), big fire is boiled, continue 6 minutes, change little fire heating 17-27 minute (preferred: little fire heating 20-24 minute; Be more preferably: little fire heating 22 minutes), collecting by filtration filtrate;

(5) spray drying step (3) gained filtrate, pulverizes and sieves dry thing and step (4) gained crude drug, makes medicated powder, adds that Mel is general makes ball, obtains honeyed pill.

The preparation method of the described preparation honeyed pill for curing the brain cancer, it is (preferred: to pulverize 120-140 mesh sieve that step (5) pulverized 100-160 mesh sieve; Be more preferably: pulverized 130 mesh sieves).

The described preparation for curing the brain cancer, be made into pharmaceutically acceptable granule, its preparation method is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, then adds Cordyceps and Carnis Pseudosciaenae, adds boiled crude drug quality 6-8 water doubly (preferred: the water adding boiled crude drug quality 7 times), big fire is boiled, continue 6 minutes, change little fire heating, collecting by filtration filtrate;

(4) get Semen Gleditsiae and Semen Impatientis to clean, be placed in saline and infiltrate, take out and dry, put into parch container, add edible oil moderate heat fry 6-14 minute (preferred: moderate heat fries 8-12 minute; Be more preferably: moderate heat fries 10 minutes), taking-up cools, and pulverizes into end;

(5) heat concentration step (3) gained filtrate and dry pulverizing, making medicated powder, medicated powder is mixed with step (4) gained medicamental pulverata, adds adjuvant and make graininess, obtain granule.

The preparation method of the described preparation granules agent for curing the brain cancer, it is (preferred: little fire heating 17-23 minute that step (3) changes little fire heating 13-27 minute; Be more preferably: little fire heating 20 minutes).

The described preparation for curing the brain cancer, be made into pharmaceutically acceptable unguentum, its preparation method is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, add Cordyceps and Carnis Pseudosciaenae again, decoct with water twice, the 6-9 that each amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality), big fire turns little fire after boiling and decocts 20 minutes, after filtration, merges twice gained filtrate;

(5) join in step (3) gained filtrate by step (4) made crude drug, heating is concentrated into thick paste, obtains unguentum.

The preparation method of the described preparation unguentum for curing the brain cancer, it is (preferred: heating is concentrated into the thick paste that relative density is 1.14-1.18 that step (5) heating is concentrated into the thick paste (70 DEG C) that relative density is 1.10-1.22; Be more preferably: heating is concentrated into the thick paste that relative density is 1.16).

Pharmaceutical formulation science for curing the brain cancer provided by the invention, preparation method is simple.In addition, its excellent part also shows:

1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, can effectively prevent and treat the state of an illness and again recur;

2, this formula is summed up through clinical practice for many years and is formed, and has effect of detoxicating and resolving stagnation of pathogens, replenishing QI to invigorate the spleen, clearing away heat to alleviate pain;

3, Chinese crude drug selected by the present invention, safety has no side effect, can long-term taking, can regulate patient body function.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1for curing the preparation of the brain cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Selaginellae Doederleinii 8 parts, Herba Agrimoniae 10 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 9 parts, Ramulus Juglandis 7 parts, Radix et Rhizoma Dysosmatis 6 parts, Herba Corydalis tailensis 11 parts, Radix Angelicae Sinensis 12 parts, Herba Ecliptae 9 parts, Cordyceps 11 parts, GOUYAHUA 8 parts, Semen Gleditsiae 6 parts, Carnis Pseudosciaenae 10 parts, Radix Fortunellae Margaritae 9 parts, Radix Morindae Officinalis 8 parts, Flos Lonicerae maackii 9 parts, Semen Impatientis 6 parts, Radix Scrophulariae 11 parts.The preparation method of the above-mentioned preparation decoction for curing the brain cancer is:

(2) Herba Selaginellae Doederleinii, Herba Agrimoniae, Ramulus Juglandis, Herba Corydalis tailensis, Herba Ecliptae and Flos Lonicerae maackii are cleaned, Steam by water bath 15 minutes, take out, drench into refined honey water, the micro-stir-fry of little fire 6 minutes, taking-up cools;

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, then adds Cordyceps and Carnis Pseudosciaenae, decocts with water twice, each amount of water is 7.5 times of boiled crude drug quality, big fire turns little fire after boiling and decocts 23 minutes, after filtration, merges twice gained filtrate;

(4) get Semen Gleditsiae and Semen Impatientis to clean, be placed in saline and infiltrate, take out and dry, put into parch container, add edible oil moderate heat and fry 10 minutes, take out, pulverize;

embodiment 2for curing the preparation of the brain cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Selaginellae Doederleinii 14 parts, Herba Agrimoniae 15 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 16 parts, Ramulus Juglandis 15 parts, Radix et Rhizoma Dysosmatis 10 parts, Herba Corydalis tailensis 15 parts, Radix Angelicae Sinensis 20 parts, Herba Ecliptae 14 parts, Cordyceps 16 parts, GOUYAHUA 15 parts, Semen Gleditsiae 12 parts, Carnis Pseudosciaenae 17 parts, Radix Fortunellae Margaritae 13 parts, Radix Morindae Officinalis 12 parts, Flos Lonicerae maackii 15 parts, Semen Impatientis 14 parts, Radix Scrophulariae 17 parts.The preparation method of the above-mentioned preparation honeyed pill for curing the brain cancer is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, take out and be placed in marmite, add Cordyceps and Carnis Pseudosciaenae again, add the water of boiled crude drug quality 7 times, big fire is boiled, continue 6 minutes, change little fire heating 22 minutes, collecting by filtration filtrate;

(5) spray drying step (3) gained filtrate, pulverized 130 mesh sieves by dry thing and step (4) gained crude drug, made medicated powder, added that Mel is general makes ball, obtained honeyed pill.

Model case: xxx, male, 45 years old.Main suit: dizzy, nauseating and visual deterioration; Medical history: patient, before 2 years, occurs the uncomfortable diseases such as dizzy, nauseating, originally thinks caused by being busy with one's work, do not take notice of, find visual deterioration subsequently, the state of an illness has and increases the weight of sign, then arrives examination in hospital, be diagnosed as the brain cancer early stage, after operative treatment, the state of an illness recovers normal substantially, before three months, patient goes health check-up because of severe headache, finds brain cancer recurrence.

Patient adopts chemotherapy and takes this example gained honeyed pill, each 3-4 grain, warm boiled water, one day twice 30 days is a course for the treatment of, after patient takes a course for the treatment of, headache syndromes is eliminated substantially, reexamine focus controls and is reduced to less than 60%, and after adhering to taking three courses for the treatment of, focus is eliminated substantially, without other uncomfortable diseases, patient consolidates again drug withdrawal after a course for the treatment of, and follow up a case by regular visits in two years, the state of an illness does not recur.

embodiment 3for curing the preparation of the brain cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Selaginellae Doederleinii 10 parts, Herba Agrimoniae 11 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10 parts, Ramulus Juglandis 9 parts, Radix et Rhizoma Dysosmatis 7 parts, Herba Corydalis tailensis 12 parts, Radix Angelicae Sinensis 14 parts, Herba Ecliptae 10 parts, Cordyceps 12 parts, GOUYAHUA 10 parts, Semen Gleditsiae 8 parts, Carnis Pseudosciaenae 12 parts, Radix Fortunellae Margaritae 10 parts, Radix Morindae Officinalis 9 parts, Flos Lonicerae maackii 10 parts, Semen Impatientis 8 parts, Radix Scrophulariae 13 parts.The preparation method of the above-mentioned preparation granules agent for curing the brain cancer is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, take out and be placed in marmite, add Cordyceps and Carnis Pseudosciaenae again, add the water of boiled crude drug quality 7 times, big fire is boiled, continue 6 minutes, change little fire heating 20 minutes, collecting by filtration filtrate;

(4) get Semen Gleditsiae and Semen Impatientis to clean, be placed in saline and infiltrate, take out and dry, put into parch container, add edible oil moderate heat and fry 10 minutes, taking-up cools, and pulverizes into end;

Model case: xxx, women, 52 years old.Medical history: patient started to occur uncomfortable disease before half a year, symptom is dizziness and tinnitus, and walk unstable, lower limb body is numb, myasthenia sense, does CT display, be brain stem glioma, because of patient body problem, be not suitable for operative treatment, then use traditional Chinese medical science expectant treatment instead to hospital.

Take this example gained granule upon somebody's introduction, each 3-4g, warm boiled water, one day twice, within 30 days, be a course for the treatment of, after patient takes a course for the treatment of, the state of an illness is stablized gradually, uncomfortable disease alleviates gradually, adhere to taking three courses for the treatment of, reviewing patient's tumor disappears substantially, does not spread, follow up a case by regular visits in 1 year, patient orthobiosis.

embodiment 4for curing the preparation of the brain cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Selaginellae Doederleinii 12 parts, Herba Agrimoniae 14 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 15 parts, Ramulus Juglandis 13 parts, Radix et Rhizoma Dysosmatis 9 parts, Herba Corydalis tailensis 14 parts, Radix Angelicae Sinensis 18 parts, Herba Ecliptae 13 parts, Cordyceps 15 parts, GOUYAHUA 13 parts, Semen Gleditsiae 10 parts, Carnis Pseudosciaenae 15 parts, Radix Fortunellae Margaritae 12 parts, Radix Morindae Officinalis 11 parts, Flos Lonicerae maackii 14 parts, Semen Impatientis 12 parts, Radix Scrophulariae 15 parts.The preparation method of the above-mentioned preparation unguentum for curing the brain cancer is:

(3) by made to step (1) (2) crude drug mixing, add Sucus Zingberis, mix moistening thoroughly 15 minutes, taking-up is placed in marmite, then adds Cordyceps and Carnis Pseudosciaenae, decocts with water twice, each amount of water is 7.5 times of boiled crude drug quality, big fire turns little fire after boiling and decocts 20 minutes, after filtration, merges twice gained filtrate;

(5) join in step (3) gained filtrate by step (4) made crude drug, heating is concentrated into the thick paste (70 DEG C) that relative density is 1.16, obtains unguentum.

Model case: xxx, male, 63 years old.Main suit: headache is swollen, speech impairment, and lower extremity functional activity is limited; , just there is the symptom of swelling of having a headache, do not take notice of at that time in medical history: patient fell down before three months because of carelessness, rear patient's body constitution obviously declines, and speak and start there is obstacle, lower limb exercise is unfavorable, to examination in hospital, CT shows brain tumor, is diagnosed as glioma further.

Because patient body situation is poor, then take this example gained unguentum, each 6-10g, warm boiled water, one day twice 30 days is a course for the treatment of, after patient takes a course for the treatment of, the headache symptom such as to swell obviously is alleviated, and ability of speaking is recovered, after taking two courses for the treatment of, all diseases of patient disappear entirely, check display, tumor disappearance 80%, after continuing to take a course for the treatment of, tumor body disappears, patient can orthobiosis, and follow up a case by regular visits in a year and a half, the state of an illness does not recur.

embodiment 5for curing the preparation of the brain cancer, be prepared from (every part of 10g) primarily of following bulk drugs: Herba Selaginellae Doederleinii 11 parts, Herba Agrimoniae 12.5 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12.5 parts, Ramulus Juglandis 11 parts, Radix et Rhizoma Dysosmatis 8 parts, Herba Corydalis tailensis 13 parts, Radix Angelicae Sinensis 16 parts, Herba Ecliptae 11.5 parts, Cordyceps 13.5 parts, GOUYAHUA 11.5 parts, Semen Gleditsiae 9 parts, Carnis Pseudosciaenae 13.5 parts, Radix Fortunellae Margaritae 11 parts, Radix Morindae Officinalis 10 parts, Flos Lonicerae maackii 12 parts, Semen Impatientis 10 parts, Radix Scrophulariae 14 parts.The preparation method of the above-mentioned preparation decoction for curing the brain cancer is:

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Herba Selaginellae Doederleinii: base is former: be the herb of Spikemoss plant selaginella doederleinii.Chemical analysis: containing hordenine-O-α-L-rhamnopyranosyloxyhy glucoside, N-methyltyramine-O-α-L-rhamnopyranosyloxyhy glucoside, (E)-hordenine-(6-O-cinnamoyl-β-D-glucopyranosyl)-(1 → 3)-α-L-rhamnopyranosyloxyhy glucoside (E)-hordenine-［ 6-O-(4-hydroxycinnamoyl)-β-D-glucopyranosyl ］-(1 → 3)-α-L-rhamnopyranosyloxyhy glucoside.Nature and flavor: sweet; Micro-hardship; Puckery; Cool; Light; Temperature.Function cures mainly: heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Cough due to lung-heat; Mastitis; Jaundice due to damp-heat; Rheumatic arthralgia; Traumatic hemorrhage.

Herba Agrimoniae: base is former: be the dry aerial parts of rosaceous plant Agrimony.Nature and flavor with return through: bitter, puckery, flat.GUIXIN, Liver Channel.Function with cure mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances, tonify deficiency.For spitting of blood, spit blood, metrostaxis, malaria, dysentery, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia, de-power impairment caused by overstrain.

Crepis crocea Babc.(C.turczaninowii C.A.Mey.): base is former: be the root that outstanding zhang of feverfew Folium Bambusae ten thousand is dark.Nature and flavor: bitter in the mouth; Sweet; Warm in nature.Function cures mainly: liver and kidney tonifying; Invigorating spleen to remove dampness.Master has a dizzy spell; Soreness of the waist and knees; Edema; Leukorrhagia infantile malnutrition; Hypogalactia.

Ramulus Juglandis: base is former: be the twig of juglandaceae plant Semen Juglandis.Nature and flavor: bitter; Puckery; Property is put down.Function cures mainly: killing parasites for relieving itching; Detoxicating and resolving stagnation of pathogens.Main scabies; Scrofula; Lump.

Radix et Rhizoma Dysosmatis: base is former: be the root and rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis, Dysosma Pleiantha and dysosma veitchii Fu.Nature and flavor: bitter in the mouth; Pungent; Cool in nature; Poisonous.Gui Jing: lung; Liver Channel.Function cures mainly: dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Main cough; Laryngopharynx swelling and pain; Scrofula; Goiter; Carbuncle; Furuncle; Venom; Traumatic injury harm; Arthromyodynia.

Herba Corydalis tailensis: base is former: be the herb of bloodroot Herba Corydalis tailensis.Nature and flavor: bitter; Be slightly cold.Gui Jing: liver; Lung meridian.Function cures mainly: dispel the wind; Heat clearing away; Pain relieving; Liver heat removing and eyesight improving.Main anemopyretic cold; Cough due to lung-heat; Pulmonary tuberculosis hemoptysis; Hepatitis; Fengshi Guanjie bones and muscles pain; Toothache; Conjunctival congestion; Cataracta.

Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.

Herba Ecliptae: base is former: be the dry aerial parts of feverfew Eclipta prostrata.Nature and flavor with return through: sweet, sour, cold.Return kidney, Liver Channel.Function with cure mainly: nourishing the liver and kidney, cooling blood for hemostasis.For the hepatic and renal YIN deficiency, odontoseisis, early whitening of beard and hair, dizzy ear toot, soreness of the waist and knees, YinXuXueRe haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.

Cordyceps: base is former: be the complex of the larva body (sclerotium) of the Stroma and host's Hepialidae insecticide Hepialus etc. thereof of section ergot fungus cordyceps sinensis bacterium.Nature and flavor: sweet; Temperature; Fragrant.Gui Jing: lung; Kidney channel.Function cures mainly: protect lung qi; Real space between skin and muscles; The kidney invigorating and essence nourishing.Main cough and asthma due to lung deficiency; Chronic cough expectorant blood; Spontaneous perspiration; Night sweat; Deficiency of the kidney sexual impotence; Seminal emission; Soreness of waist and knee joint.

GOUYAHUA: base is former: be the root of the medicinal GOUYAHUA of apocynaceae plant.Nature and flavor: bitter; Cool in nature.Function cures mainly: heat clearing away blood pressure lowering; Reducing swelling and alleviating pain.Main hypertension; Laryngopharynx swelling and pain; Stomachache.

Semen Gleditsiae: base is former: be the seed of leguminous plant Fructus Gleditsia.Nature and flavor: pungent; Temperature; Poisonous.Gui Jing: lung; Large intestine channel.Function cures mainly: loosening bowel to relieve constipation; Wind and heat eliminating; Dissipating phlegm and resolving masses.Main constipation due to dry stool; Discharging fresh blood stool; Dysentery tenesmus; Phlegm dyspnea generalized edema with distention of the chest and abdomen; Hernia pain; Scrofula; Toxic swelling; Skin ulcer tinea.

Carnis Pseudosciaenae: base is former: be the meat of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet are flat.Gui Jing: spleen; Stomach; Liver; Kidney channel.Function cures mainly: replenishing QI to invigorate the spleen; The kidney invigorating; Improving eyesight; Dysentery relieving.Main after being ill, puerperal asthenia; Hypogalactia; Lumbago due to renal deficiency; Edema; Blurring of vision; Headache; Stomachache; Dysentery.

Radix Fortunellae Margaritae: base is former: be the root of rutaceae Fructus Fortunellae Margaritae, golden bullet, Fortunella crassifolia Swingle.Nature and flavor: sour in the mouth; Bitter; Warm in nature.Gui Jing: spleen; Stomach; Liver Channel.Function cures mainly: promoting the circulation of QI to relieve pain; Dissipating phlegm and resolving masses.Main epigastric distending pain; Hernia; Puerperal abdonimal pain; Uterine prolapse; Scrofula from the beginning of.

Radix Morindae Officinalis: base is former: be the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor with return through: sweet, pungent, tepor.Return kidney, Liver Channel.Function with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.

Flos Lonicerae maackii: base is former: be stem and leaf and the flower of caprifoliaceae plant Flos Lonicerae maackii.Nature and flavor: sweet in the mouth; Light; Cold in nature.Function cures mainly: dispel the wind; Heat clearing away; Removing toxic substances.Main flu; Cough; Laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Lung abscess; Acute mastitis; Eczema.

Semen Impatientis: base is former: be the seed of Balsaminaceae plant Impatientis.In autumn, gather after fruit maturation, the impurity such as removing peel, dry.Chemical analysis: containing balsaminasterol, Parinaric Acid, Saponin, fatty oil, polysaccharide, protein, aminoacid, volatile oil, and the flavonoid such as the polysaccharid glucoside of Quercetin and the derivant of nimbecetin.Nature and flavor: pungent; Bitter; Temperature; Mild toxicity.Gui Jing: kidney; Liver; Lung meridian.Function cures mainly: clots absorbing sending down the abnormal ascending QI; Hard masses softening and resolving.Main warp closes; Dysmenorrhea; Dystocia; Retention of placenta in puerperal, dysphagic; Mass in the abdomen; Bone is choked; Dirty tooth; Sore swollen toxin.

Radix Scrophulariae: bitter in the mouth is salty, cold nature.Nontoxic.There is effect of clearing away heat and cooling blood, eliminating fire and detoxication, replenishing YIN and removing heat.Constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus is hindered for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, Tianjin.

test example 1gained of the present invention is for curing the clinical practice of the preparation (embodiment 5) of the brain cancer:

Choose crowd: in April ,-2015 in March, 2014, according to medical case history, have patient 280 example of the brain cancer in the neurosurgery screening of six hospitals, age 20-67 year, 53.1 ± 2.2 years old mean age, the course of disease 2 months-14 months, wherein male patient 153 example, female patient 127 example.

Before test, patient is divided into two groups at random, experimental group 200 example and matched group 80 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Matched group patient carries out chemotherapy, and experimental group takes products obtained therefrom of the present invention on chemotherapeutical basis, each 250-350ml, one day twice, warmly takes, and within 30 days, is a course for the treatment of.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.

Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) complete incidence graph: focus disappears completely, and maintain more than 4 weeks; (2) partial rcsponse: focus reduces more than 50%, maintains more than 4 weeks; (3) stable: focus reduces and do not reach 25%, without newborn focus less than 50% or increase; (4) develop: focus increases more than 25% or have new focus to occur.Total effective rate=complete remission rate+partial rcsponse rate.

Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:

As shown in Table 1, the total effective rate of experimental group is 84.5%, and the total effective rate 70.0% of matched group, be starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.Treatments period, there is not a routine untoward reaction in experimental group patient, and matched group patient has 13 examples to occur the uncomfortable diseases such as Nausea and vomiting, and after stopping treatment, symptom is all eliminated, and illustrates that products obtained therefrom of the present invention has no side effect safely, strengthens body immunity.

The Chinese medicine used in the present invention, Herba Selaginellae Doederleinii, Flos Lonicerae maackii heat-clearing and toxic substances removing, Herba Agrimoniae astringing to arrest bleeding, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) liver and kidney tonifying, Ramulus Juglandis detoxicating and resolving stagnation of pathogens, Radix et Rhizoma Dysosmatis stasis-dispelling and pain-killing, Herba Corydalis tailensis clearing away heat to alleviate pain, Chinese angelica blood supplementing is invigorated blood circulation, Herba Ecliptae nourishing the liver and kidney, GOUYAHUA heat clearing away blood pressure lowering, Semen Gleditsiae dissipating phlegm and resolving masses, Carnis Pseudosciaenae replenishing QI to invigorate the spleen, Radix Fortunellae Margaritae promoting the circulation of QI to relieve pain, Cordyceps, the strong muscle of Radix Morindae Officinalis the kidney invigorating, Semen Impatientis hard masses softening and resolving, Radix Scrophulariae replenishing YIN and removing heat, multiple medical material synergism, plays effect of detoxicating and resolving stagnation of pathogens, replenishing QI to invigorate the spleen, clearing away heat to alleviate pain altogether.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims

1. for curing the preparation of the brain cancer, it is characterized in that, being prepared from primarily of following bulk drugs, be mass parts: Herba Selaginellae Doederleinii 8-14; Herba Agrimoniae 10-15; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 9-16; Ramulus Juglandis 7-15; Radix et Rhizoma Dysosmatis 6-10; Herba Corydalis tailensis 11-15; Radix Angelicae Sinensis 12-20; Herba Ecliptae 9-14; Cordyceps 11-16; GOUYAHUA 8-15; Semen Gleditsiae 6-12; Carnis Pseudosciaenae 10-17; Radix Fortunellae Margaritae 9-13; Radix Morindae Officinalis 8-12; Flos Lonicerae maackii 9-15; Semen Impatientis 6-14; Radix Scrophulariae 11-17.

2. as claimed in claim 1 for curing the preparation of the brain cancer, it is characterized in that, Herba Selaginellae Doederleinii 10-12; Herba Agrimoniae 11-14; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-15; Ramulus Juglandis 9-13; Radix et Rhizoma Dysosmatis 7-9; Herba Corydalis tailensis 12-14; Radix Angelicae Sinensis 14-18; Herba Ecliptae 10-13; Cordyceps 12-15; GOUYAHUA 10-13; Semen Gleditsiae 8-10; Carnis Pseudosciaenae 12-15; Radix Fortunellae Margaritae 10-12; Radix Morindae Officinalis 9-11; Flos Lonicerae maackii 10-14; Semen Impatientis 8-12; Radix Scrophulariae 13-15(is preferably: Herba Selaginellae Doederleinii 11; Herba Agrimoniae 12.5; Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12.5; Ramulus Juglandis 11; Radix et Rhizoma Dysosmatis 8; Herba Corydalis tailensis 13; Radix Angelicae Sinensis 16; Herba Ecliptae 11.5; Cordyceps 13.5; GOUYAHUA 11.5; Semen Gleditsiae 9; Carnis Pseudosciaenae 13.5; Radix Fortunellae Margaritae 11; Radix Morindae Officinalis 10; Flos Lonicerae maackii 12; Semen Impatientis 10; Radix Scrophulariae 14).

3. the preparation for curing the brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:

4. as claimed in claim 3 for curing the preparation method of the preparation decoction of the brain cancer, it is characterized in that, step (3) big fire turns a little fire and decocts 18-28 minute (preferably: big fire is boiled a rear turn little fire and decocted 20-26 minute after boiling; Be more preferably: big fire turns little fire after boiling and decocts 23 minutes).

5. the preparation for curing the brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable honeyed pill, its preparation method is:

6. as claimed in claim 5 for curing the preparation method of the preparation honeyed pill of the brain cancer, it is characterized in that, it is (preferred: to pulverize 120-140 mesh sieve that step (5) pulverized 100-160 mesh sieve; Be more preferably: pulverized 130 mesh sieves).

7. the preparation for curing the brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:

8. as claimed in claim 7 for curing the preparation method of the preparation granules agent of the brain cancer, it is characterized in that, it is (preferred: little fire heats 17-23 minute that step (3) changes little fire heating 13-27 minute; Be more preferably: little fire heating 20 minutes).

9. the preparation for curing the brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:

10. as claimed in claim 9 for curing the preparation method of the preparation unguentum of the brain cancer, it is characterized in that, it is (preferred: heating is concentrated into the thick paste that relative density is 1.14-1.18 that step (5) heating is concentrated into the thick paste that relative density is 1.10-1.22; Be more preferably: heating is concentrated into the thick paste that relative density is 1.16).