CN104353126A - Anti-adhesive membrane and preparation method thereof - Google Patents
Anti-adhesive membrane and preparation method thereof Download PDFInfo
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- CN104353126A CN104353126A CN201410629763.2A CN201410629763A CN104353126A CN 104353126 A CN104353126 A CN 104353126A CN 201410629763 A CN201410629763 A CN 201410629763A CN 104353126 A CN104353126 A CN 104353126A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 230000000181 anti-adherent effect Effects 0.000 title claims abstract description 37
- 239000012528 membrane Substances 0.000 title abstract 4
- 229920002472 Starch Polymers 0.000 claims abstract description 74
- 239000008107 starch Substances 0.000 claims abstract description 74
- 235000019698 starch Nutrition 0.000 claims abstract description 74
- 239000007788 liquid Substances 0.000 claims abstract description 50
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
- 229920002261 Corn starch Polymers 0.000 claims description 24
- 239000008120 corn starch Substances 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 20
- 239000012153 distilled water Substances 0.000 claims description 18
- 235000013336 milk Nutrition 0.000 claims description 18
- 239000008267 milk Substances 0.000 claims description 18
- 210000004080 milk Anatomy 0.000 claims description 18
- 238000004090 dissolution Methods 0.000 claims description 10
- 206010052428 Wound Diseases 0.000 claims description 6
- 208000027418 Wounds and injury Diseases 0.000 claims description 6
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 230000007012 clinical effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 17
- 239000011521 glass Substances 0.000 description 16
- 229920002674 hyaluronan Polymers 0.000 description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 9
- 229960003160 hyaluronic acid Drugs 0.000 description 9
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- 238000010345 tape casting Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 208000031737 Tissue Adhesions Diseases 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 2
- 206010060932 Postoperative adhesion Diseases 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
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- 238000006731 degradation reaction Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000003243 intestinal obstruction Diseases 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
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- 238000002695 general anesthesia Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
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- 238000000746 purification Methods 0.000 description 1
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- 159000000000 sodium salts Chemical class 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention relates to an anti-adhesive membrane and a preparation method thereof. The anti-adhesive membrane disclosed by the invention is formed by mixing carboxymethyl starch paste liquid with starch paste liquid. The anti-adhesive membrane disclosed by the invention has the advantages of excellent clinical effect, good safety, biodegradability, simpleness in preparation method and low equipment requirement and cost and is applied to large-scale industrial production.
Description
Technical field
The present invention relates to medical material tech field, specifically a kind of Antiadhesive film and preparation method thereof.
Background technology
Adhesion is the anomalous structure that connective fiber band and adjacent tissue or organ combine and formed.Adhesion formation has universality, it is reported 50% ~ 100% abdominal cavity and operation on pelvis can cause in various degree adhesion.The clinical severe complication that adhesion causes comprises intestinal obstruction, infertility, chronic pelvic pain etc., adds the difficulty of again performing the operation and the potentiality that complication occurs further.Therefore prevent tissue adhesion from being the problem that surgical field is paid much attention to.The physical barrier effect of clinical general employing adherence preventing material prevents the generation of bonding symptom.
Current existing adherence preventing material has following several: modification of chitosan, hyaluronic acid, shuttle methylcellulose.
Modification of chitosan is more common adherence preventing material, originally has excellent biological barrier performance and histocompatibility, is applied to and organizes wound surface, prevent postoperative tissue adhesion.Chitosan, owing to having biocompatibility and organizing the features such as degradability, can be used as desirable Post operation anti-blocking agent after making film theoretically.But it is not high enough that the chitin glue used clinically at present exists purity, and poor to a lot of preventing adhesiving effect, degradation speed is difficult to artificial adjustment, the degraded of chitin is also subject to the impact of Lysozyme Levels height in human body, and assimilation effect is unpredictable.Therefore application surface is narrow.Past, in the research of prevention of postoperative adhesion, is only limitted to abdominal operation Film with Preventing Adhesion intestinal obstruction.More because create ophthalmology untoward reaction, there is Mass disturbance, just promptly halted by SFDA.
Hyaluronic acid ultimate principle is the biological agent based on hyaluronic acid biocompatibility, physics (rheology) characteristic and the uniqueness good with crosslinked hyaluronan molecule.But natural hyaluronic acid is due to shorter in implant site retention time, and its Film with Preventing Adhesion effect can not reach desirable effect.Crosslinked hyaluronic acid has good biocompatibility, and longer in in-house retention time.Since then, crosslinked hyaluronic acid is as prevention and the effective preparation reducing tissue adhesion, and its application causes to be paid attention to widely.But because hyaluronic acid is expensive, cause patient's cost of seeking medical advice high, and hyaluronic acid many genus animal sources, there is Immunogenicity in vivo, and hyaluronic acid is complicated in the process of Isolation and purification, keep high-purity difficulty very large, and have heavy-metal residual, can cause implanting rear human body poisoning.
Shuttle methylcellulose is the one of cellulose ether, and usually used is its sodium salt.It has good biocompatibility, can degradablely absorb in vivo, and degradation product is without toxicity, side effect, to peritoneum nonirritant, can reduce Postoperative Adhesion of Abdominal Cavity Surgery incidence rate and alleviate adhesion.But shuttle methylcellulose absorbs degraded fast (4 days), far fewer than the time of wound healing, usually need to add plasticizer modification and can be applied to clinical, but it is controlled not realize degradation speed.
Summary of the invention
The present invention seeks to the deficiency overcoming above-mentioned prior art, provide a kind of operation wound position that can stick to voluntarily to form physical barriers, prevent the formation of adhesion and the preparation method of medical absorbable anti-adhesion film of degrading voluntarily in wound healing process, absorbing.
A technical scheme of the present invention is:
A kind of Antiadhesive film, sticks with paste liquid by carboxymethyl starch and gelatinized corn starch liquid mixes.
Another technical scheme of the present invention is:
A preparation method for Antiadhesive film, comprises following steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with water by carboxymethyl starch, furnishing starch milk, adds glycerol, under 160 DEG C of conditions, and gelatinizing;
(2) preparation of gelatinized corn starch liquid: by starch dissolution in distilled water, puts into the water-bath of 80 DEG C; Add cross-linking agent wherein, stir;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid, stir, this solution is poured in mould, puts into baking oven dry, prepared film is placed in vacuum bag for subsequent use.
Preferably, the cross-linking agent used in step 2 is: one or more in acrylic aldehyde, formaldehyde, sodium trimetaphosphate, polyvinyl alcohol.
Preferably, the middle gelatinized corn starch liquid of step (3) and carboxymethyl starch stick with paste the ratio of liquid is 2:1 ~ 1:3.
Preferably, in step (1), the ratio of carboxymethyl starch and water is 1g:20ml ~ 1g:40ml.
Preferably, in step (3), oven temperature is 50 DEG C.
Another technical scheme of the present invention is:
Antiadhesive film of the present invention is preventing the application in wound adhesion, promotion wound healing.
Tool of the present invention has the following advantages: Antiadhesive film clinical effectiveness of the present invention is excellent, safety is good, biodegradable, and preparation method is simple, low for equipment requirements, with low cost, can apply and large-scale industrial production.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, but scope is not limited to described content.
Embodiment 1
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:20mL), furnishing starch milk, gets starch milk 50g, adds glycerol 5g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 80 DEG C; Add the aqueous solution (concentration is 20g/L) of 2ml polyvinyl alcohol wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 2
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:20mL), furnishing starch milk, gets starch milk 50g, adds glycerol 5g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 80 DEG C; Add the aqueous solution (concentration is 15g/L) of 3ml acrylic aldehyde wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 3
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:20mL), furnishing starch milk, gets starch milk 50g, adds glycerol 5g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 80 DEG C; Add 2ml formaldehyde wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 4
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:20mL), furnishing starch milk, gets starch milk 50g, adds glycerol 5g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 80 DEG C; Add the aqueous solution (concentration is 17g/L) of 3ml sodium trimetaphosphate wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 5
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:40mL), furnishing starch milk, gets starch milk 50g, adds glycerol 4g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 40min of 85 DEG C; Add the aqueous solution (concentration is 20g/L) of 2ml polyvinyl alcohol wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 2:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 6
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:40mL), furnishing starch milk, gets starch milk 50g, adds glycerol 2g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 50min of 83 DEG C; Add the aqueous solution (concentration is 15g/L) of 3ml acrylic aldehyde wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:2), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 7
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:40mL), furnishing starch milk, gets starch milk 50g, adds glycerol 3g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 82 DEG C; Add 2ml formaldehyde wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:1), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
Embodiment 8
Prepare Antiadhesive film, comprise the steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with a certain amount of water by carboxymethyl starch (ratio of starch and water is 1g:40mL), furnishing starch milk, gets starch milk 50g, adds glycerol 2g wherein, under 160 DEG C of conditions, gelatinizing 50min;
(2) preparation of gelatinized corn starch liquid: by 5g starch dissolution in the distilled water of 50mL, puts into the water-bath 30min of 80 DEG C; Add the aqueous solution (concentration is 17g/L) of 3ml sodium trimetaphosphate wherein, stir 30min;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid (both ratios are 1:3), stir, add distilled water more wherein to Glass rod hardly hanging wire, leave standstill this solution to disappearance of bubbling.This solution the tape casting is poured in glass dish (mould), puts into the dry 48h of baking oven of 50 DEG C.Prepared film is placed in vacuum bag for subsequent use.
The Antiadhesive film test effect of embodiment 9 the application
The Antiadhesive film obtained with embodiment 1-8 carries out zoopery:
Get rabbit 26, general anesthesia, cut rabbit abdominal part open along center line, take out cornua uteri, destroy the serous coat at cornua uteri position, produce hemorrhage, form wound surface.Packet transaction, Antiadhesive film application 16 is only as experimental group (Antiadhesive film that each embodiment prepares is for 2 rabbits),, as positive controls, 5 as blank group, then suturing them for " the hundred luxuriant and rich with fragrance rice " of 5 employing Beijing Bailikang Biochem Co., Ltd..To draw materials after 15 days observation.Find that the rabbit intraperitoneal of experimental group does not all produce adhesion, Antiadhesive film degraded obviously, acceptance rate is 100%, positive controls two wound delayed healings, but do not have influence on final result, and blank group intraperitoneal produces serious extensive adhesion, cornua uteri not only produces the adhesion with self, and adhesive band scope is wide and adhesion intensity is high.
Claims (8)
1. an Antiadhesive film, is characterized in that: mixed by carboxymethyl starch paste liquid and gelatinized corn starch liquid.
2. a preparation method for Antiadhesive film, is characterized in that: comprise following steps:
(1) carboxymethyl starch sticks with paste the preparation of liquid: mixed with water by carboxymethyl starch, furnishing starch milk, adds glycerol, under 160 DEG C of conditions, and gelatinizing;
(2) preparation of gelatinized corn starch liquid: by starch dissolution in distilled water, puts into the water-bath of 80 DEG C; Add cross-linking agent wherein, stir;
(3) preparation of Antiadhesive film: the gelatinized corn starch liquid that step (2) is obtained is added carboxymethyl starch obtained in step (1) and stick with paste in liquid, stir, this solution is poured in mould, puts into baking oven dry, prepared film is placed in vacuum bag for subsequent use.
3. preparation method as claimed in claim 2, is characterized in that: the cross-linking agent used in step 2 is: one or more in acrylic aldehyde, formaldehyde, sodium trimetaphosphate, polyvinyl alcohol.
4. the preparation method as described in any one of claim 2-3, is characterized in that: in step (3), gelatinized corn starch liquid and carboxymethyl starch stick with paste the ratio of liquid is 2:1 ~ 1:3.
5. the preparation method as described in any one of claim 2-4, is characterized in that: in step (1), the ratio of carboxymethyl starch and water is 1g:20ml ~ 1g:40ml.
6. the preparation method as described in any one of claim 2-5, is characterized in that: in step (3), oven temperature is 50 DEG C.
7. the Antiadhesive film that the preparation method described in any one of claim 2-6 is obtained.
8. claim 1, the Antiadhesive film described in 7 is preventing the application in wound adhesion, promotion wound healing.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104327310A (en) * | 2014-11-24 | 2015-02-04 | 江苏德威兰医疗器械有限公司 | Anti-adhesive membrane subjected to ultrasonic process treatment and preparation method thereof |
| CN105963803A (en) * | 2016-06-15 | 2016-09-28 | 湖州科达化工燃料有限公司 | Anti-adhesion membrane with antalgic and antibacterial effects |
| WO2019134725A3 (en) * | 2018-01-04 | 2019-10-03 | PlantTec Medical GmbH | Medicament containing carboxymethylated starch and a citrate and/or citric acid for use in the reduction of post-operative adhesions |
| CN115286826A (en) * | 2022-08-25 | 2022-11-04 | 陕西科技大学 | Carboxymethyl starch/chitosan/PVP composite membrane and preparation method and application thereof |
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