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ATE110729T1 - Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel. - Google Patents

Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.

Info

Publication number
ATE110729T1
ATE110729T1 AT87109416T AT87109416T ATE110729T1 AT E110729 T1 ATE110729 T1 AT E110729T1 AT 87109416 T AT87109416 T AT 87109416T AT 87109416 T AT87109416 T AT 87109416T AT E110729 T1 ATE110729 T1 AT E110729T1
Authority
AT
Austria
Prior art keywords
group
substituted
processes
preparation
antibacterial agents
Prior art date
Application number
AT87109416T
Other languages
English (en)
Inventor
Yoshiyuki Zama
Nobuo Ishiyama
Tsuneo Saita
Takanobu Naito
Masao Hirose
Masaaki Yokoyama
Taiji Asano
Hisato Senda
Keiji Sekine
Shigeru Sanai
Original Assignee
Kaken Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd filed Critical Kaken Pharma Co Ltd
Application granted granted Critical
Publication of ATE110729T1 publication Critical patent/ATE110729T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT87109416T 1986-07-01 1987-06-30 Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel. ATE110729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15270686 1986-07-01
JP19159086 1986-08-18

Publications (1)

Publication Number Publication Date
ATE110729T1 true ATE110729T1 (de) 1994-09-15

Family

ID=26481559

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87109416T ATE110729T1 (de) 1986-07-01 1987-06-30 Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.

Country Status (10)

Country Link
US (2) US4822786A (de)
EP (1) EP0251299B1 (de)
KR (1) KR930007418B1 (de)
CN (1) CN1022036C (de)
AT (1) ATE110729T1 (de)
AU (3) AU597676B2 (de)
CA (1) CA1283404C (de)
DE (1) DE3750443T2 (de)
ES (1) ES2062974T3 (de)
HU (3) HU198500B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028601A (en) * 1987-04-30 1991-07-02 Meiji Saika Kaisha, Ltd. Cephalosporin compounds and antibacterial agents
JPH0633281B2 (ja) * 1987-11-11 1994-05-02 明治製菓株式会社 新規セファロスポリン化合物及び抗菌剤
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JPH0248580A (ja) * 1988-08-10 1990-02-19 Meiji Seika Kaisha Ltd 新規セファロスポリン系化合物及び抗菌剤
EP0400805A1 (de) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporinverbindungen und ihre Verwendung
JPH03176473A (ja) * 1989-12-01 1991-07-31 Kaken Pharmaceut Co Ltd ピリジン―ｎ―オキシド誘導体及びその製法
CA2100623A1 (en) * 1992-07-17 1994-01-18 Michiyuki Sendai Cephem compounds, their production and use
JPH11124384A (ja) * 1997-10-17 1999-05-11 Otsuka Chem Co Ltd ３−セフェム化合物の製造法
US6352770B1 (en) 1999-01-15 2002-03-05 Bic Corporation Correction tape having dye migration blocking properties
PT2308874E (pt) 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
BRPI0809147A2 (pt) 2007-03-23 2014-08-26 Basilea Pharmaceutica Ag Medicamentos combinados para tratamento de infecções bacterianas
RU2599791C2 (ru) 2010-08-10 2016-10-20 Ремпекс Фармасьютикэлз, Инч. Циклические бороновые кислотно-эфирные производные и их использование в терапии
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN104994844A (zh) 2013-01-04 2015-10-21 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
BR112015016002A2 (pt) 2013-01-04 2017-07-11 Rempex Pharmaceuticals Inc compostos, composições farmacêuticas, complexos químicos e respectivos usos e método para tratar ou prevenir infecção bacteriana
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
LT3140310T (lt) 2014-05-05 2019-11-25 Rempex Pharmaceuticals Inc Boronato druskų sintezė ir jų panaudojimas
WO2015171398A1 (en) 2014-05-05 2015-11-12 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
JP6672176B2 (ja) 2014-05-19 2020-03-25 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体およびその治療的使用
JP6700203B2 (ja) 2014-07-01 2020-05-27 レンペックス・ファーマシューティカルズ・インコーポレイテッド ボロン酸誘導体およびその治療的使用
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2761778T3 (es) 2014-12-19 2020-05-21 Rempex Pharmaceuticals Inc Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
JP7377545B2 (ja) 2017-10-11 2023-11-10 キューペックス バイオファーマ， インコーポレイテッド ボロン酸誘導体およびその合成
CA3097127A1 (en) 2018-04-20 2019-10-24 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
CN112409383A (zh) * 2020-11-30 2021-02-26 上海交通大学医学院 一种氨噻肟哌啶酮头孢菌素的制备及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
JPS59167576A (ja) * 1983-03-15 1984-09-21 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS59219282A (ja) * 1983-05-28 1984-12-10 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物およびその中間体
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
GB8410289D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
NZ215527A (en) * 1985-04-01 1989-06-28 Mochida Pharm Co Ltd Cephalosporin derivatives and pharmaceutical compositions
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
HUT56099A (en) 1991-07-29
US4883879A (en) 1989-11-28
HU198500B (en) 1989-10-30
DE3750443T2 (de) 1995-04-20
EP0251299A3 (en) 1989-10-11
HU908257D0 (en) 1991-06-28
EP0251299B1 (de) 1994-08-31
KR880001674A (ko) 1988-04-26
AU635174B2 (en) 1993-03-11
ES2062974T3 (es) 1995-01-01
AU6214390A (en) 1990-12-20
HUT56071A (en) 1991-07-29
EP0251299A2 (de) 1988-01-07
KR930007418B1 (ko) 1993-08-10
CA1283404C (en) 1991-04-23
US4822786A (en) 1989-04-18
DE3750443D1 (de) 1994-10-06
HUT44259A (en) 1988-02-29
AU1962892A (en) 1992-09-10
AU627067B2 (en) 1992-08-13
AU597676B2 (en) 1990-06-07
CN87104590A (zh) 1988-01-13
AU7493187A (en) 1988-01-07
CN1022036C (zh) 1993-09-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee