AR103711A2 - Procedimiento para modificar formación de cristal de fármaco, cristales modificados y composiciones que los contienen - Google Patents
Procedimiento para modificar formación de cristal de fármaco, cristales modificados y composiciones que los contienenInfo
- Publication number
- AR103711A2 AR103711A2 ARP160100409A ARP160100409A AR103711A2 AR 103711 A2 AR103711 A2 AR 103711A2 AR P160100409 A ARP160100409 A AR P160100409A AR P160100409 A ARP160100409 A AR P160100409A AR 103711 A2 AR103711 A2 AR 103711A2
- Authority
- AR
- Argentina
- Prior art keywords
- drug substance
- crystals
- crystal habit
- procedure
- acicular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describe un procedimiento para modificar el hábito de cristal de sustancias de fármaco aciculares, cristales obtenidos a través de dicho procedimiento, y formas de cristal particulares o modificaciones de ácido micofenólico o micofenolato de sodio, así como composiciones farmacéuticas que comprenden los cristales, métodos y tratamiento y usos de los mismos. Reivindicación 1: Un procedimiento para modificar el hábito de cristal de una sustancia de fármaco acicular, caracterizada porque la sustancia de fármaco acicular es una sal de sodio de micofenolato, que comprende suspender dicha sustancia de fármaco cristalina en un sistema de solvente metanol / agua en una relación en el rango entre 98:2 y 90:10 y, y someter dicha suspensión a una oscilación de temperatura, donde el hábito de cristal es modificado y que la relación de aspecto media de los cristales procesados es menor que 10:1 y la densidad aparente es mayor que 200 kg/m³. Reivindicación 2: Un procedimiento para recristalizar una sustancia de fármaco acidular cristalina caracterizada porque la sustancia de fármaco acicular es una sal de sodio de micofenolato, que comprende suspender dicha sustancia de fármaco cristalina en un sistema de solvente metanol / agua en una relación en el rango entre 98:2 y 90:10 y, y someter dicha suspensión a una oscilación de temperatura, donde el hábito de cristal es modificado ya que la relación de aspecto media de los cristales procesados es menor que 10:1 y la densidad aparente es mayor que 200 kg/m³.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0301259.8A GB0301259D0 (en) | 2003-01-20 | 2003-01-20 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR103711A2 true AR103711A2 (es) | 2017-05-31 |
Family
ID=9951448
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100142A AR043343A1 (es) | 2003-01-20 | 2004-01-19 | Procedimiento para modificar formacion de cristal de farmaco |
| ARP160100409A AR103711A2 (es) | 2003-01-20 | 2016-02-15 | Procedimiento para modificar formación de cristal de fármaco, cristales modificados y composiciones que los contienen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100142A AR043343A1 (es) | 2003-01-20 | 2004-01-19 | Procedimiento para modificar formacion de cristal de farmaco |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20060122265A1 (es) |
| EP (2) | EP2308471A1 (es) |
| JP (1) | JP4549976B2 (es) |
| KR (5) | KR100855149B1 (es) |
| CN (2) | CN100595199C (es) |
| AR (2) | AR043343A1 (es) |
| AT (1) | ATE546132T1 (es) |
| AU (1) | AU2004206731B2 (es) |
| BR (1) | BRPI0406827A (es) |
| CA (2) | CA2706900A1 (es) |
| CL (1) | CL2004000073A1 (es) |
| CO (1) | CO5580738A2 (es) |
| CY (1) | CY1112772T1 (es) |
| DK (1) | DK1592401T3 (es) |
| EC (1) | ECSP055918A (es) |
| ES (1) | ES2382035T3 (es) |
| GB (1) | GB0301259D0 (es) |
| HK (1) | HK1084874A1 (es) |
| IL (1) | IL169484A (es) |
| MX (1) | MXPA05007691A (es) |
| MY (1) | MY148297A (es) |
| NO (1) | NO20053846L (es) |
| NZ (1) | NZ541073A (es) |
| PE (2) | PE20110276A1 (es) |
| PL (2) | PL376525A1 (es) |
| PT (1) | PT1592401E (es) |
| RU (1) | RU2388757C2 (es) |
| SG (1) | SG155046A1 (es) |
| SI (1) | SI1592401T1 (es) |
| TW (1) | TWI325785B (es) |
| WO (1) | WO2004064806A2 (es) |
| ZA (1) | ZA200504442B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124953D0 (en) | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
| GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
| AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
| EP1740564A2 (en) | 2004-04-26 | 2007-01-10 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
| CA2555461A1 (en) | 2004-04-27 | 2005-11-10 | Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
| ATE461182T1 (de) * | 2004-07-20 | 2010-04-15 | Teva Gyogyszergyar Zartkoeruen | Kristallines mycophenolat-natrium |
| GB0419355D0 (en) * | 2004-08-31 | 2004-09-29 | Novartis Ag | Organic compounds |
| US20080176937A1 (en) * | 2007-01-23 | 2008-07-24 | Apotex Fermentation Inc. | Novel crystalline mycophenolate sodium polymorph and processes to manufacture same |
| MX2011003731A (es) * | 2008-10-09 | 2011-08-03 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Uso de solventes organicos en la granulacion humeda de moxifloxacino. |
| CN101756958B (zh) * | 2008-11-10 | 2011-07-20 | 鲁南制药集团股份有限公司 | 一种治疗关节炎的药物组合物及其制备方法 |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| ES2416459T3 (es) * | 2009-07-10 | 2013-08-01 | Janssen Pharmaceutica, N.V. | Procedimiento de cristalización para 1-( -D-glucopiranosil)-4-metil-3-[5-(4-fluorofenil)-2-tienilmetil]benceno |
| WO2011046546A1 (en) * | 2009-10-13 | 2011-04-21 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
| CN108558740B (zh) | 2010-01-27 | 2021-10-19 | 艾尼纳制药公司 | S1p1受体调节剂及其盐的制备方法 |
| CA2799204C (en) | 2010-05-11 | 2018-11-06 | Janssen Pharmaceutica Nv | Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt |
| CN103880800A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
| CN103880799A (zh) * | 2010-11-16 | 2014-06-25 | 北京京卫信康医药科技发展有限公司 | 麦考酚酸钠的新晶型及其制备方法 |
| ES2586846T3 (es) | 2011-04-13 | 2016-10-19 | Janssen Pharmaceutica, N.V. | Proceso de preparación de compuestos útiles como inhibidores de SGLT2 |
| TWI582078B (zh) * | 2013-01-23 | 2017-05-11 | 北京貝美拓新藥研發有限公司 | 抑制脯氨酸羥化酶活性的化合物的晶型及其應用 |
| MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| US10323025B2 (en) * | 2015-12-21 | 2019-06-18 | Janssen Pharmaceutica Nv | Crystallization procedure for obtaining canagliflozin hemihydrate crystals |
| US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| CN108727317A (zh) * | 2017-04-25 | 2018-11-02 | 鲁南制药集团股份有限公司 | 一种麦考酚酸的晶型物 |
| CN108727318A (zh) * | 2017-04-25 | 2018-11-02 | 鲁南制药集团股份有限公司 | 麦考酚酸的晶型物 |
| CN110922371B (zh) * | 2019-12-27 | 2020-08-11 | 广东蓝宝制药有限公司 | 一种m2晶型麦考酚钠的制备方法 |
| WO2023234158A1 (ja) * | 2022-05-31 | 2023-12-07 | 本州化学工業株式会社 | ４，４'－ビス（１，１－ビス（４－ヒドロキシ－３－メチルフェニル）エチル）ビフェニルの結晶及び、その製造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US158835A (en) * | 1875-01-19 | Improvement in mortising-tools | ||
| GB935432A (en) * | 1958-05-29 | 1963-08-28 | Secr Aviation | Improvements in the manufacture of crystalline substances |
| US3187039A (en) * | 1962-10-19 | 1965-06-01 | Commercial Solvents Corp | Method for changing the crystal habit of monosodium glutamate |
| US3183263A (en) * | 1962-10-19 | 1965-05-11 | Commercial Solvents Corp | Method for changing the crystal habit of mono-sodium glutamate |
| US3352906A (en) * | 1963-02-04 | 1967-11-14 | Charles R Parkerson | Habit modification and preparation of single crystal triglycine sulfate |
| US3770390A (en) * | 1971-02-26 | 1973-11-06 | Dow Chemical Co | Crystal habit modification of inorganic salts using polymeric sulfonates or sulfates |
| US4259239A (en) * | 1980-04-21 | 1981-03-31 | Allied Chemical Corporation | Resolution of enantiomeric complexes of nickelous chloride and alpha-aminocaprolactam |
| IL60254A (en) | 1980-06-08 | 1983-11-30 | Yeda Res & Dev | Resolution of amino acids |
| JPS5875194A (ja) * | 1981-10-30 | 1983-05-06 | 株式会社日立製作所 | マトリクス表示装置及び駆動方法 |
| JPS59232916A (ja) * | 1983-06-16 | 1984-12-27 | Shiraishi Chuo Kenkyusho:Kk | 針柱状炭酸カルシウム結束体、その製造法及び該結束体を含有する感熱紙用塗被組成物 |
| IL77031A (en) | 1985-11-12 | 1995-12-08 | Yeda Res & Dev | Kinetic resolution of racemic mixtures by polymer-bound crystallization inhibitors |
| JPH0745359B2 (ja) | 1987-12-25 | 1995-05-17 | 東レ株式会社 | 有機化合物結晶の製造方法 |
| EP0582452B1 (en) * | 1992-08-04 | 1998-10-14 | Toda Kogyo Corp. | Granulated particles for magnetic particles for magnetic recording and process for producing the same |
| JP3411038B2 (ja) | 1993-09-15 | 2003-05-26 | シンテックス（ユー・エス・エイ）・インコーポレイテッド | ミコフェノール酸モフェチルの結晶質無水物およびその静注用製剤 |
| JPH09209297A (ja) * | 1996-01-26 | 1997-08-12 | Nippon Paper Ind Co Ltd | 艶消し軽量塗工紙及びその製造方法 |
| KR100491274B1 (ko) * | 1996-04-12 | 2005-09-05 | 노파르티스 아게 | 미코페놀레이트의장용코팅된약제조성물 |
| ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| FR2780403B3 (fr) * | 1998-06-24 | 2000-07-21 | Sanofi Sa | Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant |
| GB0301259D0 (en) * | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
-
2003
- 2003-01-20 GB GBGB0301259.8A patent/GB0301259D0/en not_active Ceased
-
2004
- 2004-01-19 PL PL376525A patent/PL376525A1/pl not_active Application Discontinuation
- 2004-01-19 BR BR0406827-0A patent/BRPI0406827A/pt not_active Application Discontinuation
- 2004-01-19 KR KR1020057013313A patent/KR100855149B1/ko active IP Right Grant
- 2004-01-19 MX MXPA05007691A patent/MXPA05007691A/es active IP Right Grant
- 2004-01-19 TW TW093101302A patent/TWI325785B/zh not_active IP Right Cessation
- 2004-01-19 CN CN200480002455A patent/CN100595199C/zh not_active Expired - Lifetime
- 2004-01-19 DK DK04703158.8T patent/DK1592401T3/da active
- 2004-01-19 KR KR1020107024515A patent/KR20100120321A/ko not_active Application Discontinuation
- 2004-01-19 CA CA2706900A patent/CA2706900A1/en not_active Abandoned
- 2004-01-19 PE PE2011000069A patent/PE20110276A1/es active IP Right Grant
- 2004-01-19 PL PL393385A patent/PL213192B1/pl unknown
- 2004-01-19 AT AT04703158T patent/ATE546132T1/de active
- 2004-01-19 EP EP10177718A patent/EP2308471A1/en not_active Withdrawn
- 2004-01-19 US US10/541,504 patent/US20060122265A1/en not_active Abandoned
- 2004-01-19 SI SI200431859T patent/SI1592401T1/sl unknown
- 2004-01-19 NZ NZ541073A patent/NZ541073A/en not_active IP Right Cessation
- 2004-01-19 ES ES04703158T patent/ES2382035T3/es not_active Expired - Lifetime
- 2004-01-19 AR ARP040100142A patent/AR043343A1/es unknown
- 2004-01-19 AU AU2004206731A patent/AU2004206731B2/en not_active Expired
- 2004-01-19 KR KR1020097022060A patent/KR20090115821A/ko active Search and Examination
- 2004-01-19 JP JP2005518641A patent/JP4549976B2/ja not_active Expired - Fee Related
- 2004-01-19 RU RU2005126328/04A patent/RU2388757C2/ru active
- 2004-01-19 KR KR1020077016703A patent/KR20070087181A/ko not_active Application Discontinuation
- 2004-01-19 SG SG200700660-4A patent/SG155046A1/en unknown
- 2004-01-19 CA CA2509796A patent/CA2509796C/en not_active Expired - Lifetime
- 2004-01-19 PE PE2004000074A patent/PE20040826A1/es not_active Application Discontinuation
- 2004-01-19 KR KR1020097022061A patent/KR101129105B1/ko active IP Right Grant
- 2004-01-19 MY MYPI20040142A patent/MY148297A/en unknown
- 2004-01-19 EP EP04703158A patent/EP1592401B1/en not_active Revoked
- 2004-01-19 WO PCT/EP2004/000354 patent/WO2004064806A2/en active Application Filing
- 2004-01-19 CN CNA2008101443548A patent/CN101333201A/zh active Pending
- 2004-01-19 PT PT04703158T patent/PT1592401E/pt unknown
- 2004-01-20 CL CL200400073A patent/CL2004000073A1/es unknown
-
2005
- 2005-05-31 ZA ZA200504442A patent/ZA200504442B/en unknown
- 2005-06-30 IL IL169484A patent/IL169484A/en active IP Right Grant
- 2005-07-15 EC EC2005005918A patent/ECSP055918A/es unknown
- 2005-07-25 CO CO05072728A patent/CO5580738A2/es not_active Application Discontinuation
- 2005-08-16 NO NO20053846A patent/NO20053846L/no not_active Application Discontinuation
-
2006
- 2006-04-26 HK HK06104995.1A patent/HK1084874A1/xx not_active IP Right Cessation
-
2008
- 2008-12-18 US US12/337,663 patent/US8008511B2/en not_active Expired - Lifetime
-
2011
- 2011-08-04 US US13/198,022 patent/US8124795B2/en not_active Expired - Lifetime
-
2012
- 2012-05-14 CY CY20121100450T patent/CY1112772T1/el unknown
-
2016
- 2016-02-15 AR ARP160100409A patent/AR103711A2/es not_active Application Discontinuation
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