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AR021838A1 - Nuevos bis-benzimidazoles - Google Patents

Nuevos bis-benzimidazoles

Info

Publication number
AR021838A1
AR021838A1 ARP990104911A ARP990104911A AR021838A1 AR 021838 A1 AR021838 A1 AR 021838A1 AR P990104911 A ARP990104911 A AR P990104911A AR P990104911 A ARP990104911 A AR P990104911A AR 021838 A1 AR021838 A1 AR 021838A1
Authority
AR
Argentina
Prior art keywords
hydrogen
halogen
carbon atoms
benzimidazoles
hydroxy
Prior art date
Application number
ARP990104911A
Other languages
English (en)
Original Assignee
Bayer Yakuhin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Yakuhin Ltd filed Critical Bayer Yakuhin Ltd
Publication of AR021838A1 publication Critical patent/AR021838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos Bis-benzimidazoles de la formula general (1) en la cual R1, R2, R3 y R4 son hidrogeno, hidroxi o halogeno; R5 y R6 son hidrogeno, o alquilo de1 a 4 átomos de carbono; R6 y R7 son hidrogeno, o alquilo de 1 a 6 átomos de carbono, hidroxi, halogeno, o alcoxi de 1 a 6 átomos de carbono; R9, R10 y R11son hidrogeno, halogeno, nitro, ciano, o trifluormetilo, y A es un heterociclo no aromático, de 5 a 7 miembros, etc; proceso para la preparacion y suutilizacion para tratar enfermedades asociadas con la actividad de la triptasa, tales como el asma y la rinitis alérgica.
ARP990104911A 1998-10-01 1999-09-29 Nuevos bis-benzimidazoles AR021838A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10271198P 1998-10-01 1998-10-01
US11726999P 1999-01-26 1999-01-26
US12327799P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
AR021838A1 true AR021838A1 (es) 2002-08-07

Family

ID=27379394

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990104911A AR021838A1 (es) 1998-10-01 1999-09-29 Nuevos bis-benzimidazoles

Country Status (9)

Country Link
EP (1) EP1117651A1 (es)
JP (1) JP2002526537A (es)
AR (1) AR021838A1 (es)
AU (1) AU5998199A (es)
CA (1) CA2346040A1 (es)
CO (1) CO5261509A1 (es)
GT (1) GT199900167A (es)
PE (1) PE20001057A1 (es)
WO (1) WO2000020401A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5370679A1 (es) * 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
EP1556349A1 (en) * 2002-10-11 2005-07-27 Astrazeneca AB 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
DK2802328T3 (en) * 2012-01-09 2018-06-14 X Chem Inc TRYPTOLIN DERIVATIVES WITH KINASE INHIBITIVE ACTIVITY AND APPLICATIONS THEREOF
WO2014152013A1 (en) * 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York 4-phenylpiperidines, their preparation and use
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT71345A (en) * 1993-09-22 1995-11-28 Wellcome Found Bis(amidinobenzimidazolyl)alkanes and pharmaceutical compositions containing them
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
EP1019382A1 (en) * 1997-04-07 2000-07-19 Axys Pharmaceuticals, Inc. Compounds and compositions for treating diseases associated with serine protease, particularly tryptase, activity
WO1999026932A1 (en) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. By amidino group substituted heterocyclic derivatives and their use as anticoagulants

Also Published As

Publication number Publication date
JP2002526537A (ja) 2002-08-20
GT199900167A (es) 2001-03-21
CO5261509A1 (es) 2003-03-31
PE20001057A1 (es) 2001-01-03
WO2000020401A1 (en) 2000-04-13
CA2346040A1 (en) 2000-04-13
AU5998199A (en) 2000-04-26
EP1117651A1 (en) 2001-07-25

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