AR002976A1 - Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas - Google Patents
Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadasInfo
- Publication number
- AR002976A1 AR002976A1 ARP960101937A AR10193796A AR002976A1 AR 002976 A1 AR002976 A1 AR 002976A1 AR P960101937 A ARP960101937 A AR P960101937A AR 10193796 A AR10193796 A AR 10193796A AR 002976 A1 AR002976 A1 AR 002976A1
- Authority
- AR
- Argentina
- Prior art keywords
- formulations
- insulin
- approximately
- long
- crystals
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 230000007774 longterm Effects 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se trata de formulaciones parenterales farmacéuticas de efecto prolongado, que comprenden: una suspensión acuosa estéril de aproximadamente 20 U/ml a 500U/ml de un análogo de insulina, aproximadamente 5 mg/ml a aproximadamente 10 mg /ml de cloruros ódico, aproximadamente 0,2 a 2,0 mg/ml de un tampónfisiológicamente aceptable, que contiene aproximadamente de 0,07-0,1 mg/ml de iones zinc y un conservante fisiológicamente aceptable, a un pH del orden de6,5 a 7,8; de modo que al menos 5% delanál ogo presente en la suspensión está disuelto. También se proponen los análogos de insulina cristalizados,utilizables en dichas formulaciones y la preparación de dichos análogos cristalizados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41488095A | 1995-03-31 | 1995-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002976A1 true AR002976A1 (es) | 1998-05-27 |
Family
ID=23643384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101937A AR002976A1 (es) | 1995-03-31 | 1996-03-27 | Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5952297A (es) |
| EP (1) | EP0735048A1 (es) |
| JP (1) | JPH11502856A (es) |
| KR (1) | KR19980703425A (es) |
| CN (1) | CN1185114A (es) |
| AR (1) | AR002976A1 (es) |
| AU (1) | AU720300B2 (es) |
| BR (1) | BR9607935A (es) |
| CA (1) | CA2216516A1 (es) |
| CO (1) | CO4700482A1 (es) |
| CZ (1) | CZ305297A3 (es) |
| EA (1) | EA000970B1 (es) |
| HU (1) | HUP9801700A3 (es) |
| IL (1) | IL117696A (es) |
| MX (1) | MX9707428A (es) |
| NO (1) | NO974498L (es) |
| NZ (1) | NZ305719A (es) |
| PE (1) | PE38797A1 (es) |
| PL (1) | PL322626A1 (es) |
| TR (1) | TR199701078T1 (es) |
| WO (1) | WO1996030040A1 (es) |
| YU (1) | YU18596A (es) |
| ZA (1) | ZA962502B (es) |
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| SI0884053T1 (en) * | 1997-06-13 | 2003-02-28 | Eli Lilly And Company | Stable insulin formulations |
| AR012894A1 (es) | 1997-06-13 | 2000-11-22 | Lilly Co Eli | Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma. |
| US20010053761A1 (en) * | 1998-01-08 | 2001-12-20 | Dimarchi Richard Dennis | Method for administering aspb28-human insulin |
| WO1999048520A1 (en) * | 1998-03-24 | 1999-09-30 | Joergensen Klavs Holger | Novel preparation of protracted acting human insulin |
| US6211144B1 (en) * | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
| US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| CN1125081C (zh) | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| US6734162B2 (en) | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
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| US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
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| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7713932B2 (en) | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
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| US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
| AU2003236521A1 (en) | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| US7683029B2 (en) * | 2003-05-07 | 2010-03-23 | Philip Morris Usa Inc. | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin |
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| AU2011202239C1 (en) * | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
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|---|---|---|---|---|
| US2626228A (en) * | 1945-05-17 | 1953-01-20 | Novo Terapeutisk Labor As | Method of producing crystalline insulin |
| US2882202A (en) * | 1950-04-05 | 1959-04-14 | Novo Terapeutisk Labor As | Insulin crystal preparations and methods of producing them |
| US2648622A (en) * | 1950-11-29 | 1953-08-11 | Research Corp | Purifying insulin by seeding with unclumped fibrils of insulin |
| US2882203A (en) * | 1951-06-26 | 1959-04-14 | Novo Terapeutisk Labor As | Injectable insulin preparation with protracted effect |
| DK78069C (da) * | 1952-06-23 | 1954-09-06 | Novo Terapeutisk Labor As | Fremgangsmåde til fremstilling af krystallinsk insulin. |
| US2849370A (en) * | 1953-06-04 | 1958-08-26 | Novo Terapeutisk Labortorium A | Injectable insulin preparations with protracted effect and process of producing same |
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| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
| US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| US5534488A (en) * | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| AU711428B2 (en) * | 1994-06-16 | 1999-10-14 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
-
1996
- 1996-03-27 AR ARP960101937A patent/AR002976A1/es not_active Application Discontinuation
- 1996-03-27 YU YU18596A patent/YU18596A/sh unknown
- 1996-03-28 IL IL11769696A patent/IL117696A/xx not_active IP Right Cessation
- 1996-03-28 PL PL96322626A patent/PL322626A1/xx unknown
- 1996-03-28 WO PCT/US1996/004424 patent/WO1996030040A1/en not_active Application Discontinuation
- 1996-03-28 PE PE1996000217A patent/PE38797A1/es not_active Application Discontinuation
- 1996-03-28 EP EP96302171A patent/EP0735048A1/en not_active Withdrawn
- 1996-03-28 MX MX9707428A patent/MX9707428A/es unknown
- 1996-03-28 JP JP8529728A patent/JPH11502856A/ja active Pending
- 1996-03-28 BR BR9607935A patent/BR9607935A/pt not_active Application Discontinuation
- 1996-03-28 KR KR1019970706829A patent/KR19980703425A/ko not_active Withdrawn
- 1996-03-28 EA EA199700285A patent/EA000970B1/ru not_active IP Right Cessation
- 1996-03-28 CZ CZ973052A patent/CZ305297A3/cs unknown
- 1996-03-28 TR TR97/01078T patent/TR199701078T1/xx unknown
- 1996-03-28 NZ NZ305719A patent/NZ305719A/en unknown
- 1996-03-28 CN CN96194052A patent/CN1185114A/zh active Pending
- 1996-03-28 CO CO96015449A patent/CO4700482A1/es unknown
- 1996-03-28 CA CA002216516A patent/CA2216516A1/en not_active Abandoned
- 1996-03-28 HU HU9801700A patent/HUP9801700A3/hu unknown
- 1996-03-28 AU AU53812/96A patent/AU720300B2/en not_active Ceased
- 1996-03-28 ZA ZA9602502A patent/ZA962502B/xx unknown
-
1997
- 1997-09-26 US US08/938,245 patent/US5952297A/en not_active Expired - Fee Related
- 1997-09-29 NO NO974498A patent/NO974498L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9801700A3 (en) | 1998-12-28 |
| AU720300B2 (en) | 2000-05-25 |
| IL117696A (en) | 2000-01-31 |
| ZA962502B (en) | 1997-09-29 |
| NZ305719A (en) | 1998-09-24 |
| CZ305297A3 (cs) | 1998-02-18 |
| KR19980703425A (ko) | 1998-11-05 |
| WO1996030040A1 (en) | 1996-10-03 |
| CA2216516A1 (en) | 1996-10-03 |
| MX9707428A (es) | 1997-12-31 |
| BR9607935A (pt) | 1998-06-02 |
| EP0735048A1 (en) | 1996-10-02 |
| YU18596A (sh) | 1998-07-10 |
| AU5381296A (en) | 1996-10-16 |
| EA199700285A1 (ru) | 1998-02-26 |
| IL117696A0 (en) | 1996-07-23 |
| TR199701078T1 (xx) | 1998-01-21 |
| PE38797A1 (es) | 1997-10-04 |
| CO4700482A1 (es) | 1998-12-29 |
| EA000970B1 (ru) | 2000-08-28 |
| CN1185114A (zh) | 1998-06-17 |
| US5952297A (en) | 1999-09-14 |
| PL322626A1 (en) | 1998-02-02 |
| HUP9801700A2 (hu) | 1998-11-30 |
| JPH11502856A (ja) | 1999-03-09 |
| NO974498D0 (no) | 1997-09-29 |
| NO974498L (no) | 1997-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |