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NO20065781L - Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1. - Google Patents

Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1.

Info

Publication number
NO20065781L
NO20065781L NO20065781A NO20065781A NO20065781L NO 20065781 L NO20065781 L NO 20065781L NO 20065781 A NO20065781 A NO 20065781A NO 20065781 A NO20065781 A NO 20065781A NO 20065781 L NO20065781 L NO 20065781L
Authority
NO
Norway
Prior art keywords
hydroxysteroid dehydrogenase
dehydrogenase type
inhibitors
beta
enzyme
Prior art date
Application number
NO20065781A
Other languages
Norwegian (no)
Inventor
Guolin Cai
Qi Huang
Chester Chenguang Yuan
Meredith Williams
Christopher H Fotsch
Qingyian Liu
Martin Henriksson
Evert Homan
Lars Johansson
Jerk Vallgarda
Eric Bercot
Aiwen Li
Randall W Hungate
Christopher Tegley
Jean David St
Nianhe Han
Michael D Bartberger
Georg A Moniz
Matthew J Frizzle
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0401324A external-priority patent/SE0401324D0/en
Priority claimed from SE0402509A external-priority patent/SE0402509D0/en
Priority claimed from PCT/US2005/018081 external-priority patent/WO2005116002A2/en
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of NO20065781L publication Critical patent/NO20065781L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser med formelen (I), (II), (III) eller (IV): hvor R, R, R, R, R, R, R, X og Z er som definert her, og også farmasøytiske preparater omfattende forbindelsene, så vel som metoder anvendelige for behandling av lidelser forbundet med human 11-p-hydroksysteroid dehydrogenase type 1 enzym og for fremstilling av et medikament som virker på det humane 11-P-hydroksysteroid dehydrogenase type 1 enzym.The present invention relates to compounds of formula (I), (II), (III) or (IV): wherein R, R, R, R, R, R, R, R, X and Z are as defined herein, and also pharmaceutical compositions comprising the compounds, as well as methods useful for the treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the manufacture of a medicament acting on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

NO20065781A 2004-05-24 2006-12-13 Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1. NO20065781L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0401324A SE0401324D0 (en) 2004-05-24 2004-05-24 New compounds
SE0402509A SE0402509D0 (en) 2004-10-15 2004-10-15 New compounds
US65077705P 2005-01-31 2005-01-31
PCT/US2005/018081 WO2005116002A2 (en) 2004-05-24 2005-05-24 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

Publications (1)

Publication Number Publication Date
NO20065781L true NO20065781L (en) 2007-02-08

Family

ID=41717469

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065781A NO20065781L (en) 2004-05-24 2006-12-13 Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1.

Country Status (10)

Country Link
KR (1) KR101296408B1 (en)
CR (2) CR8771A (en)
EC (1) ECSP067108A (en)
HK (1) HK1096095A1 (en)
HR (1) HRP20060456A2 (en)
IL (1) IL179167A (en)
MA (1) MA28662B1 (en)
MX (1) MXPA06013657A (en)
NO (1) NO20065781L (en)
NZ (1) NZ552284A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1614678B1 (en) 1998-07-08 2014-01-01 Sanofi-Aventis Deutschland GmbH Sulfur substituted sulfonylaminocarboxylic acid N-heteroarylamides, their preparation, their use and pharmaceutical preparations comprising them

Also Published As

Publication number Publication date
KR101296408B1 (en) 2013-08-13
CR8771A (en) 2007-07-24
KR20070058382A (en) 2007-06-08
MXPA06013657A (en) 2007-11-07
IL179167A0 (en) 2007-03-08
HRP20060456A2 (en) 2007-03-31
IL179167A (en) 2012-01-31
HK1096095A1 (en) 2007-05-25
CR20120420A (en) 2012-09-14
MA28662B1 (en) 2007-06-01
ECSP067108A (en) 2007-05-30
NZ552284A (en) 2010-01-29

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application