MA24644A1 - Methode pour la synthese des derives de la quinoline - Google Patents

Methode pour la synthese des derives de la quinoline

Info

Publication number: MA24644A1
Authority: MA; Morocco
Prior art keywords: synthesis; quinoline derivatives; quinoline; derivatives
Prior art date: 1997-09-17

Application number

MA25246A

Other languages

English (en)

Inventor

Sisko Joseph

Millinger Mark

Kowalski Conrad

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-17

Filing date

1998-09-08

Publication date

1999-04-01

1998-09-08 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1999-04-01 Publication of MA24644A1 publication Critical patent/MA24644A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA25246A 1997-09-17 1998-09-08 Methode pour la synthese des derives de la quinoline MA24644A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5930397P	1997-09-17	1997-09-17

Publications (1)

Publication Number	Publication Date
MA24644A1 true MA24644A1 (fr)	1999-04-01

Family

ID=22022126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25246A MA24644A1 (fr)	1997-09-17	1998-09-08	Methode pour la synthese des derives de la quinoline

Country Status (32)

Country	Link
US (6)	US6335448B1 (fr)
EP (1)	EP1017676B1 (fr)
JP (1)	JP2001516744A (fr)
KR (1)	KR20010024031A (fr)
CN (1)	CN1125815C (fr)
AP (1)	AP1201A (fr)
AR (1)	AR015445A1 (fr)
AT (1)	ATE353879T1 (fr)
AU (1)	AU744538B2 (fr)
BG (1)	BG104243A (fr)
BR (1)	BR9812085A (fr)
CA (1)	CA2303026A1 (fr)
DE (1)	DE69837100T2 (fr)
DZ (1)	DZ2607A1 (fr)
EA (1)	EA002633B1 (fr)
ES (1)	ES2283072T3 (fr)
HU (1)	HUP0004855A3 (fr)
ID (1)	ID24140A (fr)
IL (1)	IL134991A0 (fr)
MA (1)	MA24644A1 (fr)
MY (1)	MY120237A (fr)
NO (1)	NO314303B1 (fr)
NZ (1)	NZ503307A (fr)
OA (1)	OA11340A (fr)
PE (1)	PE129299A1 (fr)
PL (1)	PL339340A1 (fr)
SK (1)	SK3672000A3 (fr)
TR (1)	TR200000720T2 (fr)
TW (1)	TW509678B (fr)
UY (2)	UY25174A1 (fr)
WO (1)	WO1999014196A1 (fr)
ZA (1)	ZA988455B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP1201A (en) *	1997-09-17	2003-09-01	Smithkline Beecham Corp	Method for the synthesis of quinoline derivatives.
DE60004654T2 (de)	1999-03-29	2004-06-24	Neurogen Corp., Branford	4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
AU2005214159A1 (en)	2004-02-04	2005-09-01	Pfizer Products Inc.	Substituted quinoline compounds
WO2006130080A2 (fr) *	2005-06-03	2006-12-07	Astrazeneca Ab	Derives de quinoline utilises comme antagonistes de nk3
US20080194623A1 (en) *	2005-08-02	2008-08-14	Labaw Clifford S	Method for the Synthesis of Quinoline Derivatives
JP2009504642A (ja) *	2005-08-11	2009-02-05	アストラゼネカ・アクチエボラーグ	Ｎｋ−３受容体の調節剤としてのオキソピリジルキノリンアミド
CN101268052A (zh) *	2005-09-21	2008-09-17	阿斯利康(瑞典)有限公司	作为nk-3受体配体的n-氧代-杂环和n-氧代-烷基喹啉-4-甲酰胺
AR057130A1 (es) *	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
CN101410392A (zh) *	2006-01-27	2009-04-15	阿斯利康(瑞典)有限公司	酰胺取代的喹啉类化合物
CN102702099A (zh) *	2012-06-21	2012-10-03	江苏恩华药业股份有限公司	(s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN102924375B (zh) *	2012-06-21	2015-02-18	江苏恩华药业股份有限公司	Talnetant中间体及其制备方法和应用
CN103214416A (zh) *	2013-04-26	2013-07-24	扬州大学	一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2776290A (en) *		1957-01-01		Hydroxy cevchoninates and carboxylic
CN1092642C (zh) *	1994-05-27	2002-10-16	史密丝克莱恩比彻姆股份公司	用作速激肽nk3受体拮抗剂的喹啉衍生物
US5627193A (en) *	1995-02-09	1997-05-06	Mitsui Toatsu Chemicals, Inc.	Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) *	1997-09-17	2003-09-01	Smithkline Beecham Corp	Method for the synthesis of quinoline derivatives.

1998
- 1998-05-08 AP APAP/P/2000/001767A patent/AP1201A/en active
- 1998-09-08 MA MA25246A patent/MA24644A1/fr unknown
- 1998-09-08 UY UY25174A patent/UY25174A1/es not_active Application Discontinuation
- 1998-09-11 PE PE1998000868A patent/PE129299A1/es not_active Application Discontinuation
- 1998-09-14 DZ DZ980217A patent/DZ2607A1/fr active
- 1998-09-15 MY MYPI98004207A patent/MY120237A/en unknown
- 1998-09-16 AR ARP980104603A patent/AR015445A1/es not_active Application Discontinuation
- 1998-09-16 ZA ZA988455A patent/ZA988455B/xx unknown
- 1998-09-17 IL IL13499198A patent/IL134991A0/xx unknown
- 1998-09-17 ES ES98947099T patent/ES2283072T3/es not_active Expired - Lifetime
- 1998-09-17 CN CN98810978A patent/CN1125815C/zh not_active Expired - Fee Related
- 1998-09-17 BR BR9812085-9A patent/BR9812085A/pt not_active IP Right Cessation
- 1998-09-17 KR KR1020007002766A patent/KR20010024031A/ko not_active Ceased
- 1998-09-17 EP EP98947099A patent/EP1017676B1/fr not_active Expired - Lifetime
- 1998-09-17 AT AT98947099T patent/ATE353879T1/de not_active IP Right Cessation
- 1998-09-17 ID IDW20000498A patent/ID24140A/id unknown
- 1998-09-17 US US09/508,358 patent/US6335448B1/en not_active Expired - Fee Related
- 1998-09-17 CA CA002303026A patent/CA2303026A1/fr not_active Abandoned
- 1998-09-17 TR TR2000/00720T patent/TR200000720T2/xx unknown
- 1998-09-17 AU AU93958/98A patent/AU744538B2/en not_active Ceased
- 1998-09-17 DE DE69837100T patent/DE69837100T2/de not_active Expired - Lifetime
- 1998-09-17 NZ NZ503307A patent/NZ503307A/en unknown
- 1998-09-17 HU HU0004855A patent/HUP0004855A3/hu unknown
- 1998-09-17 PL PL98339340A patent/PL339340A1/xx unknown
- 1998-09-17 JP JP2000511747A patent/JP2001516744A/ja active Pending
- 1998-09-17 EA EA200000322A patent/EA002633B1/ru not_active IP Right Cessation
- 1998-09-17 WO PCT/US1998/019434 patent/WO1999014196A1/fr active IP Right Grant
- 1998-09-17 SK SK367-2000A patent/SK3672000A3/sk unknown
- 1998-09-29 TW TW087114858A patent/TW509678B/zh not_active IP Right Cessation
1999
- 1999-02-26 UY UY25407A patent/UY25407A1/es unknown
2000
- 2000-03-15 BG BG104243A patent/BG104243A/xx unknown
- 2000-03-16 NO NO20001387A patent/NO314303B1/no not_active IP Right Cessation
- 2000-03-16 OA OA1200000078A patent/OA11340A/en unknown
2001
- 2001-10-17 US US09/981,185 patent/US20020038029A1/en not_active Abandoned
2002
- 2002-06-17 US US10/174,458 patent/US20020173657A1/en not_active Abandoned
2003
- 2003-05-20 US US10/441,708 patent/US20040049031A1/en not_active Abandoned
2005
- 2005-03-30 US US11/093,701 patent/US20050171152A1/en not_active Abandoned
2006
- 2006-04-28 US US11/413,932 patent/US20060189809A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PE129299A1 (es)	2000-02-19
UY25174A1 (es)	2001-07-31
US20050171152A1 (en)	2005-08-04
DE69837100T2 (de)	2007-11-22
TW509678B (en)	2002-11-11
US20040049031A1 (en)	2004-03-11
CN1278796A (zh)	2001-01-03
EA200000322A1 (ru)	2000-10-30
EP1017676A4 (fr)	2002-12-04
CA2303026A1 (fr)	1999-03-25
JP2001516744A (ja)	2001-10-02
NO20001387L (no)	2000-03-16
NO20001387D0 (no)	2000-03-16
BG104243A (en)	2001-05-31
BR9812085A (pt)	2000-09-26
US6335448B1 (en)	2002-01-01
AU744538B2 (en)	2002-02-28
UY25407A1 (es)	1999-11-17
ID24140A (id)	2000-07-06
HUP0004855A3 (en)	2001-08-28
US20020038029A1 (en)	2002-03-28
IL134991A0 (en)	2001-05-20
EA002633B1 (ru)	2002-08-29
HUP0004855A2 (hu)	2001-06-28
KR20010024031A (ko)	2001-03-26
US20020173657A1 (en)	2002-11-21
NO314303B1 (no)	2003-03-03
EP1017676B1 (fr)	2007-02-14
DE69837100D1 (de)	2007-03-29
DZ2607A1 (fr)	2003-03-01
NZ503307A (en)	2002-04-26
PL339340A1 (en)	2000-12-18
ES2283072T3 (es)	2007-10-16
EP1017676A1 (fr)	2000-07-12
AP2000001767A0 (en)	2000-03-31
AU9395898A (en)	1999-04-05
MY120237A (en)	2005-09-30
US20060189809A1 (en)	2006-08-24
OA11340A (en)	2003-12-09
ATE353879T1 (de)	2007-03-15
ZA988455B (en)	1999-02-17
SK3672000A3 (en)	2000-09-12
WO1999014196A1 (fr)	1999-03-25
CN1125815C (zh)	2003-10-29
TR200000720T2 (tr)	2000-08-21
AP1201A (en)	2003-09-01
AR015445A1 (es)	2001-05-02

Publication	Publication Date	Title
MA24817A1 (fr)	1999-12-31	Procede de preparation de derives de la classe des taxo?des
MX199501B (es)	2000-11-10	Sintesis asimetrica de (-)6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona
DK0788496T3 (da)	2001-06-18	Inhibitorer for syntese af apolipoprotein-B
MA24632A1 (fr)	1999-04-01	Derives de 2-(4-aryl-ou heteroaryl-piperazine-1-ylmethyle)-1h- indole
MA24246A1 (fr)	1998-04-01	Procede de preparation de frites dorees au four ameliorees
MA24644A1 (fr)	1999-04-01	Methode pour la synthese des derives de la quinoline
NO990295D0 (no)	1999-01-22	FremgangsmÕte for katalytisk fremstilling av N-acylglycinderivater
NO20003454D0 (no)	2000-07-04	FremgangsmÕte for fremstilling av (-)cis-3-hydroksy-1-metyl-4-
IT1295934B1 (it)	1999-05-28	Procedimento migliorato per la sintesi di alchilpoliglucosidi
TR199800403A3 (tr)	1998-09-21	a-Bromo-laktam türevlerinin hazirlanmasi için yöntem.
NO994049D0 (no)	1999-08-23	Metode for å fremstille farmasöytiske forbindelser
FR2768725B1 (fr)	1999-11-12	Procede de preparation du 2-chloroprop-1-ene
NO20001896L (no)	2000-06-13	FremgangsmÕte for syntese av klorpurinmellomprodukter
BR9708718A (pt)	1999-08-03	Sínteses de aminas substituídas
NO20012811D0 (no)	2001-06-07	Fremgangsmåte for fremstilling av p-klorfenyl-propanol- derivat
FR2763942B1 (fr)	2002-09-13	Nouveau procede de preparation de n-acylaminoacides
FR2750998B1 (fr)	1998-09-18	Procede de preparation de k-carraghenase
NO20013044L (no)	2001-08-20	Fremgangsmåte for fremstilling av NG-substituerte deaza- adenosinderivater
NO20005396D0 (no)	2000-10-26	FremgangsmÕte for bioteknologisk oksydasjon av substituerte trimetylsykloheksenylforbindelser
EE200000369A (et)	2001-12-17	Isopropüülmetüül[2-(3-n-propoksüfenoksü)etüül]amiini valmistamise protsess
FI971964L (fi)	1997-05-07	Menetelmä 1-halo-3-trialkyylisilasnyylibentseenijohdannaisten valmistamiseksi
NO20003077L (no)	2000-06-15	FremgangsmÕte for fremstilling av klorbenzooksazolen
FR2817550B1 (fr)	2005-04-29	Procede de preparation de derives de pyrrolidine substituee
NO20002476L (no)	2000-05-12	FremgangsmÕte for fremstilling av formylimidazoler
NO994557D0 (no)	1999-09-20	Fremgangsmaate for fremstilling av arylaminotriazolopyridiner