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van Krieken et al., 2021 - Google Patents

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

van Krieken et al., 2021

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Document ID
1982242608642918934
Author
van Krieken P
Odermatt T
Borsigova M
Blüher M
Wueest S
Konrad D
Publication year
Publication venue
Molecular Metabolism

External Links

Snippet

Objective Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and revert the positive …
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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