[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Moncla et al., 2005 - Google Patents

Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials

Moncla et al., 2005

Document ID
17855924273529077748
Author
Moncla B
Hillier S
Publication year
Publication venue
Sexually transmitted diseases

External Links

Snippet

Objectives: To understand why clinical trials failed to demonstrate efficacy of nonoxynol-9 in preventing gonorrhea. Goal: To test the hypothesis that nonoyxnol-9 failed to prevent acquisition of Neisseria gonorrhoeae because most isolates are resistant to killing by …
Continue reading at journals.lww.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N-C(=NH)-NH2), isourea (N=C(OH)-NH2), isothiourea (-N=C(SH)-NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

Similar Documents

Publication Publication Date Title
Hillier et al. In vitro and in vivo: the story of nonoxynol 9
Aldunate et al. Vaginal concentrations of lactic acid potently inactivate HIV
Stafford et al. Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects
KR100336183B1 (en) Virus killing, bactericidal and spermicide suppositories
Buvé et al. The vaginal microbiota and susceptibility to HIV
GREAVES et al. Clindamycin versus metronidazole in the treatment of bacterial vaginosis
Zeitlin et al. Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models
Sutyak et al. Spermicidal activity of the safe natural antimicrobial peptide subtilosin
Thormar et al. Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro.
Bosserman et al. Utility of antimicrobial susceptibility testing in Trichomonas vaginalis–infected women with clinical treatment failure
Zaneveld et al. Efficacy and safety of a new vaginal contraceptive antimicrobial formulation containing high molecular weight poly (sodium 4-styrenesulfonate)
Patton et al. Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina)
Weber et al. Chemical condoms’ for the prevention of HIV infection: evaluation of novel agents against SHIV89. 6PDin vitro and in vivo
Brittingham et al. The antimicrobial effect of boric acid on Trichomonas vaginalis
Achilles et al. Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis
CN113613733A (en) Topical, isotonic compositions for genital use
Clarke et al. Microflora changes with the use of a vaginal microbicide
Patton et al. Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model
Stafford et al. A Placebo-controlled, Double-blind Prospective Study in Healthy Female Volunteers of Dextrin Sulphate Gel:: A Novel Potential Intravaginal Virucide
Moncla et al. Testing of viscous anti-HIV microbicides using Lactobacillus
Watts et al. The effects of three nonoxynol-9 preparations on vaginal flora and epithelium
Stone et al. Vaginal microbicides for preventing the sexual transmission of HIV
Moncla et al. Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials
US20050238728A1 (en) Synergistic topically applied personal hygiene product
Bukusi et al. Topical penile microbicide use by men to prevent recurrent bacterial vaginosis in sex partners: a randomized clinical trial