Macdonald-Obermann et al., 2012 - Google Patents
Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imagingMacdonald-Obermann et al., 2012
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- 15491595120456797826
- Author
- Macdonald-Obermann J
- Piwnica-Worms D
- Pike L
- Publication year
- Publication venue
- Proceedings of the National Academy of Sciences
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Snippet
Binding of EGF to its receptor induces dimerization of the normally monomeric receptor. Activation of its intracellular tyrosine kinase then occurs through the formation of an asymmetric kinase dimer in which one subunit, termed the “receiver” kinase, is activated by …
- 102000001301 EGF receptors 0 title abstract description 105
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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