[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Katounina et al., 1998 - Google Patents

Synthesis and biological investigations of [18F] MR18445, a 5-HT3 receptor partial agonist

Katounina et al., 1998

Document ID
12544297207451340358
Author
Katounina T
Besret L
Dhilly M
Petit-Taboué M
Barbelivien A
Baron J
Dauphin F
Barré L
Publication year
Publication venue
Bioorganic & medicinal chemistry

External Links

Snippet

18F Labelled MR18445 (4-[4-(4-[18F] fluorobenzyl) piperazino]-7-methoxypyrrolo [1, 2-α] quinoxaline), a selective 5-HT3 receptor partial agonist with nanomolar affinity, was synthesized and examined as a potential radioligand for PET imaging of brain 5HT3 …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds; Labelled organic compounds per se
    • C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Similar Documents

Publication Publication Date Title
Ametamey et al. Molecular imaging with PET
Saigal et al. Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
Efange et al. Synthesis and tissue distribution of iodine-125-labeled (m-[125I] iodobenzyl) trozamicol ([125I] MIBT): potential radioligand for mapping central cholinergic innervation
Lee Collier et al. Synthesis of [18F]‐1‐(3‐Fluoropropyl)‐4‐(4‐cyanophenoxymethyl)‐piperidine: A potential sigma‐1 receptor radioligand for PET
Rowland et al. Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled σ2-receptor ligands
Katounina et al. Synthesis and biological investigations of [18F] MR18445, a 5-HT3 receptor partial agonist
Chattopadhyay et al. Synthesis and evaluation of nicotine α4β2 receptor radioligand, 5-(3′-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy) pyridine, in rodents and PET in nonhuman primate
Suehiro et al. Radiosynthesis and evaluation of N-(3-[18F] fluoropropyl) paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET
Damont et al. Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: a [11C]-N-desmethyl-loperamide PET study in nonhuman primates
Klenner et al. Kinetic isotope effects and synthetic strategies for deuterated carbon-11 and fluorine-18 labelled PET radiopharmaceuticals
McConathy et al. Synthesis and biological evaluation of [11C] talopram and [11C] talsupram: candidate PET ligands for the norepinephrine transporter
Loc'h et al. Preparation of [76Br] FLB 457 and [76Br] FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET
US20090297443A1 (en) Labeled ALPHA4BETA2 Ligands and Methods Therefor
Roger et al. Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl) prop-1-ynyl]-1, 3-dihydrobenzoimidazol-2-[11C] one, as a potent NR1A/2B subtype selective NMDA PET radiotracer
Lakshminarayanan et al. Fully automated synthesis of O-(2′-[18F] fluoroethyl)-l-tyrosine ([18F] FET) using solid phase extraction (SPE) purification with neutral alumina
Wang et al. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand:(S)-(+)-and (R)-(-)-[18F] FBFP
Dhawan et al. Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R‐[125/131I] AM2233
Pithia et al. Synthesis and evaluation of (S)-[18F] fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors
WO2008083454A1 (en) Process for flavonoids radiolabeling and its application on in vivo diagnosis of brain malfunctions related to benzodiazepine receiving sites
Lindberg et al. Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors
Ravert et al. [11C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers
Shiue et al. Fluorine-18 and carbon-11 labeled amphetamine analogs—synthesis, distribution, binding characteristics in mice and rats and a PET study in monkey
Valette et al. 18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors—in vitro binding properties and PET studies in baboons
Ryzhikov et al. Preparation of [1 8 F] Flumazenil, a Potential Radioligand for PET Imaging of Central Benzodiazepine Receptors, by Isotope Exchange
Alonso Martinez et al. Development of a novel [18F] fluorobenzyl derivative of the AT1 receptor antagonist Candesartan