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Scholz et al., 2001 - Google Patents

Mechanism of Tet repressor induction by tetracyclines: length compensates for sequence in the α8-α9 loop

Scholz et al., 2001

Document ID
8927705674257845284
Author
Scholz O
Kintrup M
Reich M
Hillen W
Publication year
Publication venue
Journal of Molecular Biology

External Links

Snippet

Natural Tet repressor (TetR) variants are α-helical proteins bearing a large loop between helices 8 and 9, which is variable in sequence and length. We have deleted this loop consisting of 14 amino acid residues in TetR (D) and rebuilt it stepwise with up to 42 alanine …
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    • C12N15/09—Recombinant DNA-technology
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