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Minns et al., 2022 - Google Patents

Neutrophil IL-1β secretion induced by ExoS expressing Pseudomonas aeruginosa is dependent on NLRP3 and Gasdermin D

Minns et al., 2022

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Document ID
8908864440583691935
Author
Minns M
Lima T
Liboro K
Abbondante S
Marshall M
Rietsch A
Dubyak G
Pearlman E
Publication year

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Snippet

Macrophages infected with Gram-negative bacteria expressing flagellin or Type III secretion system (T3SS) structural proteins are known to activate the NLRC4 inflammasome, resulting in caspase-1 and Gasdermin D (GSDMD) cleavage, IL-1β secretion and pyroptotic cell …
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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