Collections open to submissions
T cell responses to influenza
Guest Editor
Stefan Schattgen, PhD, St. Jude Children’s Research Hospital, USA
Submission Status: Open until 28 October 2025
Barrier immunology
Guest Editor
Hernán Peñaloza, PhD, Pontifical Catholic University of Chile, Chile
Submission Status: Open until 23 August 2025
Macrophage polarization
Guest Editor
Danli Xie, PhD, Wenzhou Medical University, China
Submission Status: Open until 20 March 2025
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Aims and scope
Articles
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Association of the systemic immune-inflammation index with clinical outcomes in acute myocardial infarction patients with hypertension
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Effect of conditioned medium from miRNA-34a transfected gastric cancer-associated fibroblast on peripheral blood mononuclear cells
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Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV
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Detecting the preoperative peripheral blood systemic immune-inflammation index (SII) as a tool for early diagnosis and prognosis of gallbladder cancer
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Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis - a prospective, observational study
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Characterization of murine macrophages from bone marrow, spleen and peritoneum
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Transcriptional profiling of the LPS induced NF-κB response in macrophages
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Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
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HLA class I supertypes: a revised and updated classification
Editor's Choice
Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases
Depression has been extensively linked to dysregulated HPA axis function, chronic inflammation and cardiovascular diseases. While the former two have been studied in depth, the mechanistic connection between depression and cardiovascular disease is unclear. In this review, we aim to discuss (1) endothelial dysfunction in depression, (2) inflammation in depression, (3) general glucocorticoid resistance in depression and (4) endothelial glucocorticoid resistance in depression co-morbid inflammatory diseases.
Transcriptomic evidence for atopic dermatitis as a systemic disease in NC/Nga mice
Kim and colleagues evaluated whether atopic dermatitis (AD) affects the entire body rather than being limited to skin barrier damage and inflammation. Using NC/Nga mice with AD-like symptoms, we compared the transcriptomes of the skeletal muscle (a tissue that is relatively distant from the skin) with those of the skin (the lesion induction site) before and after disease induction, after which Hc was administered. Although further study is needed to better understand the effects of Ces1d on AD, skeletal muscle was associated with AD pathogenesis, and AD-like symptoms appeared to affect the body in a systemic manner.
Annual Journal Metrics
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Citation Impact 2023
Journal Impact Factor: 2.9
5-year Journal Impact Factor: 3.3
Source Normalized Impact per Paper (SNIP): 0.775
SCImago Journal Rank (SJR): 0.815
Speed 2024
Submission to first editorial decision (median days): 6
Submission to acceptance (median days): 134
Usage 2024
Downloads: 678,146
Altmetric mentions: 179