Different surgical procedure have been developed in order to enhance the repair of articular cartilage, that is a common problem in orthopaedics. One stage cartilage repair is a promising approach: delivering a viable cell source in a scaffold without ex vivo cell expansion. Aim of the study is to show a new “one-stage” surgical procedure for cartilage repair combining “in situ” minced autologous cartilage fragments with a moldable resorbable scaffold composed of fibrin glue, a high molecular weight hyaluronic acid derivative and autologous platelet-enriched plasma. Chondrocytes outgrowth into the scaffold is demonstrated in explants cultures of rabbit and human. Repair process in cartilage healing is evaluated in-vivo on animal model (24 rabbits) with morphological and histological analysis and improved of treated defects compared to controls.
One-stage autologous cartilage repair with chondral fragments in a mixed scaffold (winner of ESSKA-dj ORTHO Grant 2006).
CASTOLDI, Filippo;ROSSI, Roberto;TARONE, Guido;PEIRONE, Bruno;MAUTHE DEGERFELD, Mitzy;GIACALONE, FRANCESCO
2008-01-01
Abstract
Different surgical procedure have been developed in order to enhance the repair of articular cartilage, that is a common problem in orthopaedics. One stage cartilage repair is a promising approach: delivering a viable cell source in a scaffold without ex vivo cell expansion. Aim of the study is to show a new “one-stage” surgical procedure for cartilage repair combining “in situ” minced autologous cartilage fragments with a moldable resorbable scaffold composed of fibrin glue, a high molecular weight hyaluronic acid derivative and autologous platelet-enriched plasma. Chondrocytes outgrowth into the scaffold is demonstrated in explants cultures of rabbit and human. Repair process in cartilage healing is evaluated in-vivo on animal model (24 rabbits) with morphological and histological analysis and improved of treated defects compared to controls.| File | Dimensione | Formato | |
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