The SingleCellSimulationView plugin can be used to run CellML models which consists of either a system of ordinary differential equations (ODEs) or differential algebraic equations (DAEs). The system may be non-linear.
Upon opening a CellML file, OpenCOR will check that it can be used for simulation. If it cannot, then a message will describe the issue:
Alternatively, if the CellML file is valid, then the view will look as follows:
To simulate a model, you need to provide some information about the simulation itself, i.e. its starting point, ending point and point interval. Then, you need to specify the solver that you want to use. The solvers available to you will depend on which solver plugins you selected, as well as on the type of your model (i.e. ODE or DAE). In the present case, we are dealing with an ODE model and all the solver plugins are selected, so OpenCOR offers both CVODE and Forward Euler as possible solvers for our model.
Each solver comes with its own set of properties which you can customise. For example, if we select Forward Euler as our solver, we can customise its Step
property:
At this stage, we can run our model by pressing the F9 key or by clicking on the button. Then, or before, we can decide on a model parameter to be plotted against the variable of integration (which, here, is time since the simulation properties are expressed in milliseconds). All the model parameters are listed to the left of the view, grouped by components in which they were originally defined. To select a model parameter, click on its corresponding check box:
As can be seen, the simulation failed. Several model parameters, including the one we selected, have a nan
value (i.e. not a number). In this case, it is because the solver was not properly set up. Its Step
property is too big. If we set it to 0.01 milliseconds
, reset the model parameters (by clicking on the button), and restart the simulation, then we get the following trace:
The (roughly) same trace can also be obtained using CVODE as our solver:
However, the simulation is so quick to run that we do not get a chance to see the progress of the simulation. Between the and
buttons, there is a wheel which we can use to add a short delay between the output of two data points. Here, we set the delay to
13 ms
. This allows us to rerun the simulation, after having reset the model parameters, and pause it at a point of interest:
Now, we can modify any of the model parameters identified by the icon, but let us just modify
g_Na_max
(under the sodium_channel
component) by setting its value to 0 milliS_per_cm2
. Then, we resume the simulation and we can see the effect on the model:
If we want, we could export all the simulation data to a comma-separated values (CSV) file. To do so, we need to click on the button.
To simulate a DAE model is similar to simulating an ODE model, except that OpenCOR only offers one DAE solver (IDA) at this stage:
So far, we have only simulated CellML 1.0 models, but we can also simulate CellML 1.1 models, i.e. models which import units and/or components from other models:
Each simulation is run in its own thread which means that several simulations can be run at the same time. Simulations running in the 'background' display a small progress bar in the top tab bar while the 'foreground' simulation uses the main progress bar at the bottom of the view:
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Run the simulation |
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Pause the simulation |
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Stop the simulation |
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Reset all the model parameters |
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Export the simulation data to CSV |