ENZYME entry: EC 2.7.7.100

Accepted Name
SAMP-activating enzyme
Alternative Name(s)
SAMP-activating enzyme E1
Reaction catalysed
[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate
Comment(s)
The enzyme catalyzes the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalyzing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage. The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin. Alternatively, the enzyme can also catalyze the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC 6.2.1.55).
Cross-references
BRENDA	2.7.7.100
EC2PDB	2.7.7.100
ExplorEnz	2.7.7.100
PRIAM enzyme-specific profiles	2.7.7.100
KEGG Ligand Database for Enzyme Nomenclature	2.7.7.100
IUBMB Enzyme Nomenclature	2.7.7.100
IntEnz	2.7.7.100
MEDLINE	Find literature relating to 2.7.7.100
MetaCyc	2.7.7.100
Rhea expert-curated reactions	2.7.7.100

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