ENZYME entry: EC 2.7.7.97
| Accepted Name | |||
|---|---|---|---|
| 3-hydroxy-4-methylanthranilate adenylyltransferase | |||
| Alternative Name(s) | |||
| 4-MHA-activating enzyme | |||
| actinomycin synthase I | |||
| Reaction catalysed | |||
| 3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate | |||
| Comment(s) | |||
| The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4- methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein. | |||
| Cross-references | |||
| BRENDA | 2.7.7.97 | ||
| EC2PDB | 2.7.7.97 | ||
| ExplorEnz | 2.7.7.97 | ||
| PRIAM enzyme-specific profiles | 2.7.7.97 | ||
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.7.97 | ||
| IUBMB Enzyme Nomenclature | 2.7.7.97 | ||
| IntEnz | 2.7.7.97 | ||
| MEDLINE | Find literature relating to 2.7.7.97 | ||
| MetaCyc | 2.7.7.97 | ||
| Rhea expert-curated reactions | 2.7.7.97 | ||
| UniProtKB/Swiss-Prot |
| ||
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