ENZYME entry: EC 2.7.11.37

Accepted Name
MAST-subfamily kinase
Alternative Name(s)
microtubule-associated serine/threonine-protein kinase
Reaction catalysed
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)
Comment(s)
MAST (Microtubule Associated Serine/Threonine) kinases are eukaryotic-wide kinases with roles in microtubule function, PTEN regulation and a variety of neuronal functions. They are found in most eukaryotes, though lost from most fungi and ciliates. MAST kinases associate with their substrates via their PDZ domains. Substrates include EC 3.1.3.67 in human and nematodes, and Dlic (Dynein light intermediate chain) in Drosophila. The latter is phosphorylated on Ser(401).
Cross-references
BRENDA	2.7.11.37
EC2PDB	2.7.11.37
ExplorEnz	2.7.11.37
PRIAM enzyme-specific profiles	2.7.11.37
KEGG Ligand Database for Enzyme Nomenclature	2.7.11.37
IUBMB Enzyme Nomenclature	2.7.11.37
IntEnz	2.7.11.37
MEDLINE	Find literature relating to 2.7.11.37
MetaCyc	2.7.11.37
Rhea expert-curated reactions	2.7.11.37

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