ENZYME entry: EC 2.7.1.195

Accepted Name

protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase

Alternative Name(s)

2-O-alpha-mannosyl-D-glycerate PTS permease

Reaction catalysed

(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]

Comment(s)

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS).
The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it.
The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9.
Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency.
The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
Formerly EC 2.7.1.69.

Cross-references

BRENDA

2.7.1.195

EC2PDB

2.7.1.195

ExplorEnz

2.7.1.195

PRIAM enzyme-specific profiles

2.7.1.195

KEGG Ligand Database for Enzyme Nomenclature

2.7.1.195

IUBMB Enzyme Nomenclature

2.7.1.195

IntEnz

2.7.1.195

MEDLINE

Find literature relating to 2.7.1.195

MetaCyc

2.7.1.195

Rhea expert-curated reactions

2.7.1.195

UniProtKB/Swiss-Prot

P54745, MNGA_ECOLI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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