ENZYME entry: EC 2.5.1.132

Accepted Name
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase
Alternative Name(s)
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase
KDN 9-P synthase
Reaction catalysed
aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate
Comment(s)
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-nononate (KDN). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyze the reaction. KDN is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
Cross-references
BRENDA	2.5.1.132
EC2PDB	2.5.1.132
ExplorEnz	2.5.1.132
PRIAM enzyme-specific profiles	2.5.1.132
KEGG Ligand Database for Enzyme Nomenclature	2.5.1.132
IUBMB Enzyme Nomenclature	2.5.1.132
IntEnz	2.5.1.132
MEDLINE	Find literature relating to 2.5.1.132
MetaCyc	2.5.1.132
Rhea expert-curated reactions	2.5.1.132

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