ID   2.5.1.58
DE   protein farnesyltransferase.
AN   CAAX farnesyltransferase.
AN   FTase.
CA   L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-
CA   farnesyl-L-cysteinyl-[protein] + diphosphate.
CC   -!- This enzyme, along with EC 2.5.1.59 and EC 2.5.1.60, constitutes the
CC       protein prenyltransferase family of enzymes.
CC   -!- Catalyzes the formation of a thioether linkage between the C-1 of an
CC       isoprenyl group and a cysteine residue fourth from the C-terminus of
CC       the protein.
CC   -!- These protein acceptors have the C-terminal sequence CA(1)A(2)X,
CC       where the terminal residue, X, is preferably serine, methionine,
CC       alanine or glutamine; leucine makes the protein a substrate for
CC       EC 2.5.1.59.
CC   -!- The enzymes are relaxed in specificity for A(1), but cannot act if
CC       A(2) is aromatic.
CC   -!- Substrates of the prenyltransferases include Ras, Rho, Rab, other
CC       Ras-related small GTP-binding proteins, gamma-subunits of
CC       heterotrimeric G-proteins, nuclear lamins, centromeric proteins and
CC       many proteins involved in visual signal transduction.
DR   Q9LX33, FNTA_ARATH ;  P29702, FNTA_BOVIN ;  Q9Y765, FNTA_CANAX ;
DR   Q54RT9, FNTA_DICDI ;  P49354, FNTA_HUMAN ;  Q61239, FNTA_MOUSE ;
DR   O24304, FNTA_PEA   ;  Q04631, FNTA_RAT   ;  O60052, FNTA_SCHPO ;
DR   P93227, FNTA_SOLLC ;  P29703, FNTA_YEAST ;  Q38920, FNTB_ARATH ;
DR   P49355, FNTB_BOVIN ;  Q55D51, FNTB_DICDI ;  P49356, FNTB_HUMAN ;
DR   Q8K2I1, FNTB_MOUSE ;  Q04903, FNTB_PEA   ;  G4MY67, FNTB_PYRO7 ;
DR   Q02293, FNTB_RAT   ;  O13782, FNTB_SCHPO ;  P22007, FNTB_YEAST ;
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