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ENZYME

ENZYME entry: EC 2.4.1.222

Accepted Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Alternative Name(s)
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase
Reaction catalysed
  • 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)
  • 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP + H(+)
Comment(s)
  • The enzyme, found in animals and plants, is involved in the biosynthesis of the tetrasaccharide alpha-Neu5A-(2->3)-beta-D-Gal- (1->4)-beta-D-GlcNAc-(1->3)-L-alpha-Fuc, which is attached to L-Ser or L-Thr residues within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys in EGF-like domains.
  • The substrate is provided by EC 2.4.1.221.
Cross-references
BRENDA2.4.1.222
EC2PDB2.4.1.222
ExplorEnz2.4.1.222
PRIAM enzyme-specific profiles2.4.1.222
KEGG Ligand Database for Enzyme Nomenclature2.4.1.222
IUBMB Enzyme Nomenclature2.4.1.222
IntEnz2.4.1.222
MEDLINEFind literature relating to 2.4.1.222
MetaCyc2.4.1.222
Rhea expert-curated reactions2.4.1.222
UniProtKB/Swiss-Prot
Q24342, FNG_DROMEQ2KJ92, LFNG_BOVINO12971, LFNG_CHICK
Q8JHF2, LFNG_DANREQ8NES3, LFNG_HUMANO09010, LFNG_MOUSE
Q924T4, LFNG_RATP79948, LFNG_XENLAQ5YB40, MFNG_DANRE
O00587, MFNG_HUMANO09008, MFNG_MOUSEQ5IS64, MFNG_PANTR
O12972, RFNG_CHICKQ6KFX9, RFNG_DANREQ9Y644, RFNG_HUMAN
O09009, RFNG_MOUSEQ9YHB3, RFNG_NOTVIQ9R1U9, RFNG_RAT
P79949, RFNG_XENLA

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