ENZYME entry: EC 2.4.1.146

Accepted Name

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N- acetylglucosaminyltransferase

Alternative Name(s)

elongation 3beta-GalNAc-transferase

O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II

Reaction catalysed

3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + UDP + H(+)
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + UDP + H(+)

Comment(s)

The enzyme catalyzes the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

Q9Y2A9, B3GN3_HUMAN

Q5JCS9, B3GN3_MOUSE

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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