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ENZYME

ENZYME entry: EC 2.3.1.296

Accepted Name
omega-hydroxyceramide transacylase
Reaction catalysed
an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base + a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol = an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base + a diacylglycerol
Comment(s)
  • The enzyme participates in the production of acylceramides in the stratum corneum, the outermost layer of the epidermis.
  • Acylceramides are crucial components of the skin permeability barrier.
Cross-references
BRENDA2.3.1.296
EC2PDB2.3.1.296
ExplorEnz2.3.1.296
PRIAM enzyme-specific profiles2.3.1.296
KEGG Ligand Database for Enzyme Nomenclature2.3.1.296
IUBMB Enzyme Nomenclature2.3.1.296
IntEnz2.3.1.296
MEDLINEFind literature relating to 2.3.1.296
MetaCyc2.3.1.296
Rhea expert-curated reactions2.3.1.296
UniProtKB/Swiss-Prot
Q8N8W4, PLPL1_HUMANQ3V1D5, PLPL1_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-