ENZYME entry: EC 2.3.1.289

Accepted Name
aureothin polyketide synthase system
Alternative Name(s)
aureothin polyketide synthase complex
Reaction catalysed
4-nitrobenzoyl-CoA + 4 (S)-methylmalonyl-CoA + malonyl-CoA + 4 NADPH + 8 H(+) = demethylluteothin + 5 CO2 + 4 NADP(+) + 6 CoA + 3 H2O
Comment(s)
This polyketide synthase, characterized from the bacterium Streptomyces thioluteus, generates the backbone of the antibiotic aureothin. It is composed of 4 modules that total 18 domains and is encoded by three genes. The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 4 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA. The first module (encoded by aurA) is used twice in an iterative fashion, so that the five Claisen condensation reactions are catalyzed by only four modules. The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).
Cross-references
BRENDA	2.3.1.289
EC2PDB	2.3.1.289
ExplorEnz	2.3.1.289
PRIAM enzyme-specific profiles	2.3.1.289
KEGG Ligand Database for Enzyme Nomenclature	2.3.1.289
IUBMB Enzyme Nomenclature	2.3.1.289
IntEnz	2.3.1.289
MEDLINE	Find literature relating to 2.3.1.289
MetaCyc	2.3.1.289
Rhea expert-curated reactions	2.3.1.289

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