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ENZYME

ENZYME entry: EC 2.3.1.161

Accepted Name
lovastatin nonaketide synthase
Reaction catalysed
holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + S-adenosyl-L-methionine + 11 NADPH + 19 H(+) = dihydromonacolin L-[lovastatin nonaketide synthase] + S-adenosyl-L-homocysteine + 9 CO2 + 11 NADP(+) + 9 CoA + 6 H2O
Comment(s)
  • This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase.
  • The PKS catalyzes many of the chain building reactions of EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.
Cross-references
BRENDA2.3.1.161
EC2PDB2.3.1.161
ExplorEnz2.3.1.161
PRIAM enzyme-specific profiles2.3.1.161
KEGG Ligand Database for Enzyme Nomenclature2.3.1.161
IUBMB Enzyme Nomenclature2.3.1.161
IntEnz2.3.1.161
MEDLINEFind literature relating to 2.3.1.161
MetaCyc2.3.1.161
Rhea expert-curated reactions2.3.1.161
UniProtKB/Swiss-Prot
Q9Y8A5, LOVB_ASPTEQ0C8M3, LOVB_ASPTNQ9Y7D0, LOVC_ASPTE
Q0C8M1, LOVC_ASPTNQ3S2T9, MOKA_MONPI

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