More Web Proxy on the site http://driver.im/

ENZYME

ENZYME entry: EC 2.3.1.9

Accepted Name

acetyl-CoA C-acetyltransferase

Alternative Name(s)

acetoacetyl-CoA thiolase

Reaction catalysed

2 acetyl-CoA = acetoacetyl-CoA + CoA

Comment(s)

The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms.
The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA.
In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

Find literature relating to 2.3.1.9

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

Q9FIK7, AACT1_ARATH	Q8S4Y1, ACCT2_ARATH	P76461, ATOB_ECOLI
P44873, ATOB_HAEIN	Q9I2A8, ATOB_PSEAE	Q0KBP1, BKTB_CUPNH
B0XMC1, ER10A_ASPFC	Q4WLA8, ER10A_ASPFU	I1RMA2, ER10A_GIBZE
B0YA65, ER10B_ASPFC	Q4WCL5, ER10B_ASPFU	I1RY81, ER10B_GIBZE
A0A1D8PH52, ERG10_CANAL	P10551, ERG10_SACMO	Q9UQW6, ERG10_SCHPO
P41338, ERG10_YEAST	P66927, FADA4_MYCBO	P46707, FADA4_MYCLE
A0R1Y7, FADA4_MYCS2	P9WG68, FADA4_MYCTO	P9WG69, FADA4_MYCTU
Q12598, THIA_CANTR	Q04677, THIB_CANTR	Q9BWD1, THIC_HUMAN
Q8CAY6, THIC_MOUSE	Q5XI22, THIC_RAT	Q921H8, THIKA_MOUSE
P21775, THIKA_RAT	Q8VCH0, THIKB_MOUSE	P07871, THIKB_RAT
P09110, THIK_HUMAN	Q86AD9, THIL1_DICDI	Q6NU46, THILA_XENLA
Q6GN02, THILB_XENLA	P45369, THIL_ALLVD	Q29RZ0, THIL_BOVIN
Q9ZHI1, THIL_CHRVO	P14611, THIL_CUPNH	Q6AZA0, THIL_DANRE
P24752, THIL_HUMAN	Q8HXY6, THIL_MACFA	Q8QZT1, THIL_MOUSE
P54810, THIL_PARDE	P14610, THIL_PIG	P17764, THIL_RAT
P50174, THIL_RHIME	P07097, THIL_SHIZO	P73825, THIL_SYNY3
P45363, THIL_THIVI	Q5BKN8, THIL_XENTR	Q6L8K7, THIL_YARLI
Q3T0R7, THIM_BOVIN	P42765, THIM_HUMAN	Q8BWT1, THIM_MOUSE
Q5RES5, THIM_PONAB	P13437, THIM_RAT	Q58944, THIOL_METJA
O26884, THIOL_METTH	A0A384E138, THIOL_METTL	P45359, THLA_CLOAB
Q18AR0, THLA_CLOD6	P45362, THLA_CLODI	P81347, THLA_CLOPA
Q2FJQ9, THLA_STAA3	Q2G124, THLA_STAA8	Q2YVF5, THLA_STAAB
Q5HIU0, THLA_STAAC	Q99WM3, THLA_STAAM	Q7A7L2, THLA_STAAN
Q6GJW4, THLA_STAAR	Q6GCB8, THLA_STAAS	Q8NY95, THLA_STAAW
Q5HS07, THLA_STAEQ	Q8CQN7, THLA_STAES	Q0AVM3, THLA_SYNWW
P45855, THL_BACSU	Q46939, YQEF_ECOLI

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-