ENZYME entry: EC 2.1.1.382

Accepted Name
methoxylated aromatic compound--corrinoid protein Co-methyltransferase
Reaction catalysed
a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
Comment(s)
This entry stands for a family of enzymes that have been characterized from acetogenic bacteria and archaeal species. Different members of this family have different substrate specificity. In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in acetogenic bacteria and in non-methanogenic archaea it participates in methoxydotrophic growth. Most of the enzymes have a wide specificity and were shown to act on a large number of methoxylated aromatic compounds, carrying a methoxy group at positions 2, 3 or 4 of the aromatic ring. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state; during methylation the cobalt is oxidized to the Co(III) state.
Cross-references
BRENDA	2.1.1.382
EC2PDB	2.1.1.382
ExplorEnz	2.1.1.382
PRIAM enzyme-specific profiles	2.1.1.382
KEGG Ligand Database for Enzyme Nomenclature	2.1.1.382
IUBMB Enzyme Nomenclature	2.1.1.382
IntEnz	2.1.1.382
MEDLINE	Find literature relating to 2.1.1.382
MetaCyc	2.1.1.382
Rhea expert-curated reactions	2.1.1.382

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