ENZYME entry: EC 2.1.1.375

Accepted Name

NNS virus cap methyltransferase

Reaction catalysed

a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H(+)

Comment(s)

The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses) catalyzes two successive methylations.
In higher eukaryotes the two methylations occur in the reverse order and are catalyzed by two different enzymes (cf. EC 2.1.1.56 and EC 2.1.1.57) that do not required a specific motif.

Cross-references

BRENDA

2.1.1.375

EC2PDB

2.1.1.375

ExplorEnz

2.1.1.375

PRIAM enzyme-specific profiles

2.1.1.375

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.375

IUBMB Enzyme Nomenclature

2.1.1.375

IntEnz

2.1.1.375

MEDLINE

Find literature relating to 2.1.1.375

MetaCyc

2.1.1.375

Rhea expert-curated reactions

2.1.1.375

UniProtKB/Swiss-Prot

Q9QSP0, L_ABLVB	Q8JTG9, L_ABLVH	Q2Y2L8, L_AMPV1
Q9E784, L_BEFVB	O91940, L_BRSVA	P24658, L_CDVO
P13179, L_CHAV	C6S3N3, L_DMSVA	A4UHQ2, L_EBLV1
A4UHQ7, L_EBLV2	Q91DD4, L_EBORE	Q8JPX5, L_EBORR
Q66802, L_EBOSM	Q5XX01, L_EBOSU	Q6V1Q2, L_EBOZ5
Q05318, L_EBOZM	O89344, L_HENDH	Q77SJ8, L_HIRRV
Q6WB93, L_HMPVC	Q9IWW8, L_HRSV	P28887, L_HRSVA
O36635, L_HRSVB	Q82707, L_IHNVO	Q82685, L_IHNVW
Q5K2K3, L_ISFV	Q8B0U2, L_LBVAV	Q4W382, L_LNYV3
Q1PD54, L_MABVA	P31352, L_MABVM	Q6UY63, L_MABVO
P35262, L_MABVP	Q1PDC4, L_MABVR	P35975, L_MEASA
Q9WMB3, L_MEASC	P12576, L_MEASE	Q6E0W6, L_MMVR
P0C568, L_MOKV	Q50EW2, L_MPV15	P30929, L_MUMPM
P11205, L_NDVB	Q9DLD3, L_NDVB1	Q997F0, L_NIPAV
P35946, L_PHODV	P26676, L_PI2HT	P12577, L_PI3H4
Q88434, L_PIV5	Q03396, L_PIV5W	Q4F8Z9, L_RABVA
Q66T60, L_RABVB	Q0GBX5, L_RABVD	A3F5L9, L_RABVE
Q8B6J5, L_RABVH	A3RM23, L_RABVI	Q9IPJ5, L_RABVN
P11213, L_RABVP	Q0GBY0, L_RABVR	P16289, L_RABVS
P41357, L_RINDR	O10378, L_RYSV	Q9DUD8, L_SENDA
P06829, L_SENDE	Q06996, L_SENDF	O55528, L_SENDO
P06447, L_SENDZ	Q9QJT4, L_SHRV	P35341, L_SV41
Q91DR9, L_SVCV	P31332, L_SYNV	Q5GA85, L_TAVCV
D8V078, L_TIBVC	Q4VKV2, L_TUPVT	P03523, L_VSIVA
Q8B0H0, L_VSIVC	Q98776, L_VSIVM	Q8B0I0, L_VSIVN
Q8B0H5, L_VSIVS	P13615, L_VSNJH	P16379, L_VSNJO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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