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ENZYME

ENZYME entry: EC 2.1.1.360

Accepted Name
[histone H3]-lysine(79) N-trimethyltransferase
Reaction catalysed
L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • The enzyme successively methylates the L-lysine(79) residue of histone H3 (H3K79), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail.
Cross-references
BRENDA2.1.1.360
EC2PDB2.1.1.360
ExplorEnz2.1.1.360
PRIAM enzyme-specific profiles2.1.1.360
KEGG Ligand Database for Enzyme Nomenclature2.1.1.360
IUBMB Enzyme Nomenclature2.1.1.360
IntEnz2.1.1.360
MEDLINEFind literature relating to 2.1.1.360
MetaCyc2.1.1.360
Rhea expert-curated reactions2.1.1.360
UniProtKB/Swiss-Prot
Q6AW06, DOT11_CAEELQ55AX2, DOT1L_DICDIQ8INR6, DOT1L_DROME
Q8TEK3, DOT1L_HUMANQ4WVH4, DOT1_ASPFUQ2U696, DOT1_ASPOR
Q5A309, DOT1_CANALQ6FNM5, DOT1_CANGAQ2H9L1, DOT1_CHAGB
Q1DKD8, DOT1_COCIMP0CN15, DOT1_CRYNBP0CN14, DOT1_CRYNJ
Q6BTC8, DOT1_DEBHAQ5BH89, DOT1_EMENIQ756E1, DOT1_EREGS
Q4IJP1, DOT1_GIBZEQ6CWV1, DOT1_KLULAQ7SB74, DOT1_NEUCR
Q4P2W8, DOT1_USTMAQ6C4Y5, DOT1_YARLIQ04089, DOT1_YEAST
A0A140C435, SETD4_ARTPA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-