ENZYME entry: EC 2.1.1.115

Accepted Name
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Alternative Name(s)
(RS)-tetrahydrobenzylisoquinoline N-methyltransferase
norreticuline N-methyltransferase
Reaction catalysed
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine + H(+)
Comment(s)
Broad substrate specificity for (RS)-1-benzyl-1,2,3,4- tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine. Both R- and S-enantiomers are methylated. Participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants. The physiological substrate is likely to be coclaurine. Was earlier termed norreticuline N-methyltransferase. However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1- benzyl-1,2,3,4-tetrahydroisoquinolines.
Cross-references
BRENDA	2.1.1.115
EC2PDB	2.1.1.115
ExplorEnz	2.1.1.115
PRIAM enzyme-specific profiles	2.1.1.115
KEGG Ligand Database for Enzyme Nomenclature	2.1.1.115
IUBMB Enzyme Nomenclature	2.1.1.115
IntEnz	2.1.1.115
MEDLINE	Find literature relating to 2.1.1.115
MetaCyc	2.1.1.115
Rhea expert-curated reactions	2.1.1.115

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