ENZYME entry: EC 4.2.1.122

Accepted Name
tryptophan synthase (indole-salvaging)
Alternative Name(s)
tryptophan synthase beta2
Reaction catalysed
indole + L-serine = L-tryptophan + H2O
Comment(s)
Most mesophilic bacteria have a multimeric tryptophan synthase complex (EC 4.2.1.20) that forms L-tryptophan from L-serine and 1-C- (indol-3-yl)glycerol 3-phosphate via an indole intermediate. This intermediate, which is formed by the alpha subunits, is transferred in an internal tunnel to the beta units, which convert it to tryptophan. In thermophilic organisms the high temperature enhances diffusion and causes the loss of indole. This enzyme, which does not combine with the alpha unit to form a complex, salvages the lost indole back to L-tryptophan. It has a much lower Km for indole than the beta subunit of EC 4.2.1.20.
Cross-references
BRENDA	4.2.1.122
EC2PDB	4.2.1.122
ExplorEnz	4.2.1.122
PRIAM enzyme-specific profiles	4.2.1.122
KEGG Ligand Database for Enzyme Nomenclature	4.2.1.122
IUBMB Enzyme Nomenclature	4.2.1.122
IntEnz	4.2.1.122
MEDLINE	Find literature relating to 4.2.1.122
MetaCyc	4.2.1.122
Rhea expert-curated reactions	4.2.1.122

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