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ENZYME

ENZYME entry: EC 4.2.1.80

Accepted Name
2-oxopent-4-enoate hydratase
Alternative Name(s)
2-keto-4-pentenoate hydratase
OEH
Reaction catalysed
(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O
Comment(s)
  • The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds.
  • Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer.
  • The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate.
  • However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate.
  • In some organisms the enzyme forms a complex with EC 4.1.1.77.
Cross-references
BRENDA4.2.1.80
EC2PDB4.2.1.80
ExplorEnz4.2.1.80
PRIAM enzyme-specific profiles4.2.1.80
KEGG Ligand Database for Enzyme Nomenclature4.2.1.80
IUBMB Enzyme Nomenclature4.2.1.80
IntEnz4.2.1.80
MEDLINEFind literature relating to 4.2.1.80
MetaCyc4.2.1.80
Rhea expert-curated reactions4.2.1.80
UniProtKB/Swiss-Prot
Q9KWS4, AMNF_PSESPQ47HM0, MHPD1_DECARQ400K2, MHPD1_PSEPU
Q47GC8, MHPD2_DECARQ49KF9, MHPD2_PSEPUQ706S1, MHPD3_PSEPU
C1DRI8, MHPD_AZOVDA4JPX9, MHPD_BURVGQ9S156, MHPD_COMTE
A7ZI97, MHPD_ECO24B7L506, MHPD_ECO55Q8XEC1, MHPD_ECO57
B5Z2Q5, MHPD_ECO5EB7NK05, MHPD_ECO7IB7MPB7, MHPD_ECO81
B7M2Z8, MHPD_ECO8AA7ZWZ7, MHPD_ECOHSP77608, MHPD_ECOLI
B7N8Q7, MHPD_ECOLUB1LIN5, MHPD_ECOSMA6TAC6, MHPD_KLEP7
B2JQV8, MHPD_PARP8Q13VU0, MHPD_PARXLQ3Z556, MHPD_SHISS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-