40S ribosomal protein S21 is a protein, encoded in humans by the RPS21 gene.[5][6][7]
Function
editRibosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins.
It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
Interactions
editRPS21 has been shown to interact with Ribosomal protein SA.[8][9]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000171858 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039001 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bhat KS, Morrison SG (Jun 1993). "Primary structure of human ribosomal protein S21". Nucleic Acids Research. 21 (12): 2939. doi:10.1093/nar/21.12.2939. PMC 309688. PMID 8332502.
- ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
- ^ a b "Entrez Gene: RPS21 ribosomal protein S21".
- ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- ^ Sato M, Saeki Y, Tanaka K, Kaneda Y (Mar 1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochemical and Biophysical Research Communications. 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. PMID 10079194.
Further reading
edit- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
- Kostanian IA, Astapova MV, Starovoĭtova EV, Dranitsyna SM, Lipkin VM (Apr 1995). "[A new differentiation factor from culture media of the HL-60 cell line treated with retinoic acid. Isolation and primary structure determination]". Bioorganicheskaia Khimiia. 21 (4): 243–8. PMID 7786314.
- Kostanyan IA, Astapova MV, Starovoytova EV, Dranitsina SM, Lipkin VM (Dec 1994). "A new human leukemia cell 8.2 kDa differentiation factor: isolation and primary structure". FEBS Letters. 356 (2–3): 327–9. doi:10.1016/0014-5793(94)01306-3. PMID 7805865. S2CID 43322576.
- Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A (Jul 1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". European Journal of Biochemistry. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sato M, Saeki Y, Tanaka K, Kaneda Y (Mar 1999). "Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system". Biochemical and Biophysical Research Communications. 256 (2): 385–90. doi:10.1006/bbrc.1999.0343. PMID 10079194.
- Smirnova EV, Rakitina TV, Evtodienko A, Kostanian IA, Lipkin VM (May 2000). "Cloning and characterization of the human ribosomal protein S21 gene [". Bioorganicheskaia Khimiia. 26 (5): 392–6. PMID 10900511.
- Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (Mar 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
- Yu Y, Ji H, Doudna JA, Leary JA (Jun 2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Science. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
- Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
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