Flight 901 is an airline flight number that has had multiple accidents and incidents over the years. As so, the designation may refer to:
- Austrian Airlines Flight 901, a Vickers Viscount crash near Moscow Sheremetyevo Airport, on 26 September 1960, 31 killed
- Paradise Airlines Flight 901A, crashed on the city of Lake Tahoe, California, United States, March 1, 1964, killing all 85 occupants
- Sterling Airways Flight 901, a Sud-Aviation Caravelle which experienced a landing gear failure which subsequently ruptured the fuel tank, killing 15 people on 15 March, 1974
- Air New Zealand Flight 901, a McDonnell Douglas DC-10 collision with Mount Erebus, Antarctica, on 28 November 1979, 257 killed
- Austral Líneas Aéreas Flight 901, a BAC One-Eleven crash near Buenos Aires, on May 7 1981, 31 killed
- Scandinavian Airlines System Flight 901, a McDonnell Douglas DC-10 runway excursion at John F. Kennedy Airport, on 28 February 1984; all 177 survived
- Vieques Air Link Flight 901A, crashed into the Atlantic Ocean off Vieques, Puerto Rico, August 2, 1984, killing all 9 occupants.
- Alas Chiricanas Flight 901, a Embraer EMB 110 Bandeirante bombing in Panama, on 19 July 1994, 21 killed
- Aviateca Flight 901, a Boeing 737-200 collision with San Vicente volcano, El Salvador, on 9 August 1995, 65 killed