ORC3

ORC3
Identifiers
Aliases	ORC3, LAT, LATHEO, ORC3L, origin recognition complex subunit 3
External IDs	OMIM: 604972; MGI: 1354944; HomoloGene: 8225; GeneCards: ORC3; OMA:ORC3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,667,453 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,614,944 bp
RNA expression pattern
	Top expressed in
	triceps brachii muscle; ; Achilles tendon; ; ventricular zone; ; glutes; ; gonad; ; embryo; ; ganglionic eminence; ; testicle; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	genital tubercle; ; tail of embryo; ; spermatocyte; ; epiblast; ; zygote; ; ventricular zone; ; maxillary prominence; ; neural layer of retina; ; mandibular prominence; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA replication origin binding; protein binding;
Cellular component	nuclear origin of replication recognition complex; origin recognition complex; nucleus; nucleoplasm; nuclear pre-replicative complex; DNA replication preinitiation complex; nuclear body;
Biological process	G1 phase; DNA replication; neural precursor cell proliferation; DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	23595
	50793
	ENSG00000135336
	ENSMUSG00000040044
	Q9UBD5
	Q9JK30
	NM_001197259; NM_012381; NM_181837
	NM_001159563; NM_015824
	NP_001184188; NP_036513; NP_862820
	NP_001153035; NP_056639
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex (ORC) subunit 3 N-terminus
Origin recognition complex (ORC) subunit 3 N-terminus
Identifiers
Symbol	ORC3_N
Pfam	PF07034
InterPro	IPR010748
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.^[5]^[6]^[7]

Function

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[7]

Interactions

ORC3 has been shown to interact with:

MCM4,^[8]
MCM7,^[8]
ORC2,^[6]^[8]^[9]^[10]^[11]
ORC4,^[6]^[9]^[11]
ORC5,^[6]^[8]^[9]^[11] and
ORC6.^[8]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135336 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.
^ ^a ^b ^c ^d Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. S2CID 781511.
^ ^a ^b "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".
^ ^a ^b ^c ^d ^e Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
^ ^a ^b ^c Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
^ Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.
^ ^a ^b ^c ^d Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Springer J, Nanda I, Hoehn K, Schmid M, Grummt F (2000). "Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex". Cytogenetics and Cell Genetics. 87 (3–4): 245–51. doi:10.1159/000015435. PMID 10702681. S2CID 29132152.
Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. doi:10.1074/jbc.M005765200. PMID 10954718.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.
Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.
Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. PMID 12614612.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. Bibcode:2004Sci...305...86R. doi:10.1126/science.1097639. PMID 15232106. S2CID 20936301.
Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex". Biochemistry. 44 (21): 7885–96. doi:10.1021/bi047327n. PMID 15910003.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040044 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9829972-5] Tugal T, Zou-Yang XH, Gavin K, Pappin D, Canas B, Kobayashi R, Hunt T, Stillman B (Dec 1998). "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p". The Journal of Biological Chemistry. 273 (49): 32421–9. doi:10.1074/jbc.273.49.32421. PMID 9829972.

[pmid10402192-6] Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi:10.1016/S0896-6273(00)80752-7. PMID 10402192. S2CID 781511.

[entrez-7] "Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)".

[pmid12614612-8] Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.

[pmid11395502-9] Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi:10.1074/jbc.M103078200. PMID 11395502.

[pmid17525332-10] Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. Bibcode:2007Sci...316.1160M. doi:10.1126/science.1140321. PMID 17525332. S2CID 16648052.

[pmid11323433-11] Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. PMID 11323433.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

Function

Interactions

References

Further reading