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Arylacetonitrilase

From Wikipedia, the free encyclopedia
arylacetonitrilase
Identifiers
EC no.3.5.5.5
CAS no.132053-06-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an arylacetonitrilase (EC 3.5.5.5) is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetonitrile + 2 H2O 4-chlorophenylacetate + NH3

Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H2O, whereas its two products are 4-chlorophenylacetate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.

References

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  • Mauger J, Nagasawa T, Yamada H (1990). "Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3". Arch. Microbiol. 155: 1–6. doi:10.1007/BF00291265.
  • Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization". Eur. J. Biochem. 194 (3): 765–72. doi:10.1111/j.1432-1033.1990.tb19467.x. PMID 2269298.