Cathepsin O

CTSO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ATK, 1AU0, 1AU2, 1AU3, 1AU4, 1AYU, 1AYV, 1AYW, 1BGO, 1BY8, 1MEM, 1NL6, 1NLJ, 1Q6K, 1SNK, 1TU6, 1U9V, 1U9W, 1U9X, 1VSN, 1YK7, 1YK8, 1YT7, 2ATO, 2AUX, 2AUZ, 2BDL, 2R6N, 3C9E, 3H7D, 3KW9, 3KWB, 3KWZ, 3KX1, 3O0U, 3O1G, 3OVZ, 4DMX, 4DMY, 7PCK, 4LEG, 4N79, 4N8W
Identifiers
Aliases	CTSO, CTSO1, cathepsin O
External IDs	OMIM: 600550; MGI: 2139628; HomoloGene: 1020; GeneCards: CTSO; OMA:CTSO - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,953,912 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	81,864,032 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gallbladder; ; endometrium; ; right coronary artery; ; smooth muscle tissue; ; placenta; ; gastric mucosa; ; liver; ; duodenum; ; monocyte;
	Top expressed in
	gastrula; ; mesenteric lymph nodes; ; otolith organ; ; utricle; ; median eminence; ; carotid body; ; Epithelium of choroid plexus; ; left lobe of liver; ; decidua; ; white adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity;
Cellular component	lysosome; extracellular space;
Biological process	proteolysis involved in cellular protein catabolic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	1519
	229445
	ENSG00000256043
	ENSMUSG00000028015
	P43234
	Q8BM88
	NM_001334
	NM_177662
	NP_001325
	NP_808330
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin O is an enzyme encoded by the CTSO gene in humans.^[5]^[6]

Function

Cathepsin O is a cysteine cathepsin, a cysteine protease and a member of the cathepsin family. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases, and its proteolytic activity was abolished by an inhibitor of cysteine proteinase.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000256043 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028015 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.
^ ^a ^b "Entrez Gene: cathepsin O".

External links

The MEROPS online database for peptidases and their inhibitors: C01.035

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000256043 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028015 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790772-5] Santamaría I, Pendás AM, Velasco G, López-Otín C (October 1998). "Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO)". Genomics. 53 (2): 231–4. doi:10.1006/geno.1997.5180. PMID 9790772.

[entrez-6] "Entrez Gene: cathepsin O".

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v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

References

Further reading

External links