370 results found
    1. Neuroscience

    Synchronous activity patterns in the dentate gyrus during immobility

    Martin Pofahl, Negar Nikbakht ... Heinz Beck
    Two-photon in vivo calcium imaging reveals short time-scale, synchronous and sparse population activity in dentate gyrus that replays place-related information, and is important for formation of dentate-dependent spatial memory.
    1. Developmental Biology
    2. Neuroscience

    Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

    Amir Rattner, Chantelle E Terrillion ... Jeremy Nathans
    A mouse mutant in which nearly all dentate gyrus granule cells fail to develop provides a new window on the role of the dentate gyrus in spatial learning and memory.
    1. Neuroscience

    Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

    Mengqiao Cui, Xiaoyuan Pan ... Jun-Li Cao
    RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impairment.
    1. Developmental Biology
    2. Neuroscience

    Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

    Branden R Nelson, Rebecca D Hodge ... Robert F Hevner
    Multiphoton live-imaging illuminates the dynamic underpinnings of how different types of progenitor cells migrate and interact to robustly build the mammalian Dentate Gyrus neural circuitry and new outer neurogenic niche.
    1. Computational and Systems Biology
    2. Neuroscience

    Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

    Diego M Arribas, Antonia Marin-Burgin, Luis G Morelli
    Heterogeneity in the population of granule cells in the dentate gyrus, which includes immature and mature neurons with distinct intrinsic properties, contributes to the population's enhanced encoding capabilities and ability to discriminate correlated stimuli.
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello, Christophe Galichet ... Robin Lovell-Badge
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.
    1. Neuroscience

    Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

    Elijah A Petter, Isabella P Fallon ... Henry H Yin
    Mice can learn to press a lever persistently for activation of a dopaminergic projection from the locus coeruleus to the hippocampal dentate gyrus.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

    John Darby Cole, Jacobo Sarabia del Castillo ... Sebastian Jessberger
    Iterative immunostaining using 4i enables detailed characterization of complex mouse and human tissues.
    1. Developmental Biology
    2. Neuroscience

    Adult-born neurons modify excitatory synaptic transmission to existing neurons

    Elena W Adlaf, Ryan J Vaden ... Linda Overstreet-Wadiche
    The formation of new neurons in the adult dentate gyrus causes a proportion of cortical neurons to transfer their existing connections to the newborn cells.
    1. Developmental Biology
    2. Neuroscience

    Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

    Youngshik Choe, Trung Huynh, Samuel J Pleasure
    During development the Sonic Hedgehog protein is produced by epithelial structures and acts at a distance in the brain and perhaps in other organs.

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