546 results found
    1. Neuroscience

    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

    Hongsheng Zhang, Anupama Sathyamurthy ... Lin Mei
    Enriched environment stimulates neuron generation in the hippocampus by a novel pathway involving Agrin, Lrp4, and Ror2.
    1. Computational and Systems Biology
    2. Neuroscience

    A functional model of adult dentate gyrus neurogenesis

    Olivia Gozel, Wulfram Gerstner
    The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    AAV ablates neurogenesis in the adult murine hippocampus

    Stephen Johnston, Sarah L Parylak ... Matthew Shtrahman
    Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
    1. Neuroscience

    The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

    Ronen Reshef, Elena Kudryavitskaya ... Raz Yirmiya
    During adult neurogenesis in the olfactory bulb, microglia regulate the elimination (pruning), formation, and maintenance of synapses on newborn neurons, contributing to the functional integrity of the olfactory bulb circuitry.
    1. Neuroscience

    Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

    Elizabeth D Kirby, Sandra E Muroy ... Daniela Kaufer
    Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla, Marcos Assis Nascimento ... Arturo Álvarez-Buylla
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Neuroscience

    Adult-born neurons facilitate olfactory bulb pattern separation during task engagement

    Wankun L Li, Monica W Chu ... Takaki Komiyama
    Adult-born neurons in the olfactory bulb allow state-dependent pattern separation of representations of similar odorants.
    1. Stem Cells and Regenerative Medicine

    Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis

    Corentin Bernou, Marc-André Mouthon ... François Dominique Boussin
    Characterization of an abundant clonogenic and multipotent population of immature neuroblasts, at the transition between transient-amplifying progenitor (TAP) neuroblasts and migratory neuroblasts, reversibly engaged in neuronal differentiation.
    1. Neuroscience

    Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

    Jia-Min Zhuo, Hua-an Tseng ... Xue Han
    Adult neurogenesis, although happening at a slow rate in the adult brain, plays an important role in learning and memory and has the ability to powerfully modulate large scale neural networks.
    1. Developmental Biology

    Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

    Ko W Currie, Alyssa M Molinaro, Bret J Pearson
    Planarian brain neurons modulate their turnover by signaling to nearby stem cells.

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