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Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Protective Effects of Hydroxychalcones on Free Radical-Induced Cell Damage
Satoshi SOGAWAYasunori NIHROHiroki UEDATokutaro MIKIHitoshi MATSUMOTOToshio SATOH Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Drug Development Laboratories, Nippon Hypox Lab. Inc. 9420 Nanbu
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
Faculty of Pharmaceutical Sciences, Tokushima Bunri University">
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JOURNAL FREE ACCESS

1994 Volume 17 Issue 2 Pages 251-256

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Abstract

A number of hydroxychalcones were synthesized to evaluate their protective effects against oxidative cell damage and the production of superoxide anion. The hydroxychalcones which have a 3, 4-dihydroxycinnamoyl structure were potent inhibitors of lipid peroxidation in rat liver microsomes. In particular, we found that 2', 4', 3, 4-tetrahydroxychalcone (3) exhibited a potent inhibitory effect on H2O2-induced hemolysis due to an antioxidant effect. In addition, this compound strongly inhibited CCl4-induced cytotoxicity in primary cultured hepatocytes and substantially decreased the production of superoxide anion by rat peritoneal exudate macrophages.

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© The Pharmaceutical Society of Japan
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