Silver(I)–glutathione biocoordination polymer hydrogel: effective antibacterial activity and improved cytocompatibility

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Silver(i)–glutathione biocoordination polymer hydrogel: effective antibacterial activity and improved cytocompatibility†

Yong Liu,^a Wanshun Ma,^a Wenwen Liu,^a Chao Li,^a Yaling Liu,*^a Xingyu Jiang^a and Zhiyong Tang*^a

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* Corresponding authors

^a National Center for Nanoscience and Technology, Beijing, China
E-mail: zytang@nanoctr.cn, liuyl@nanoctr.cn
Fax: +86-10-62656765
Tel: +86-10-82545580

Abstract

A Ag(I)–glutathione biocoordination polymer hydrogel is fabricated and further cross-linked by Ca²⁺ ions. Compared with commercial silver sulfadiazine cream, the cross-linked Ag(I)–glutathione hydrogel exhibits effective antibacterial activity and improved cytocompatibility, which represents the first antibacterial hydrogel based on biocoordination polymers and has potential application in the biomedical field, e.g., burn wound dressings.

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Article information

DOI: https://doi.org/10.1039/C1JM13693C
Article type: Communication
Submitted: 02 Aug 2011
Accepted: 17 Oct 2011
First published: 07 Nov 2011

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J. Mater. Chem., 2011,21, 19214-19218

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