Neoplasma Vol.57, No.1, p.86-92, 2010
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| Title: Polymorphism in heme oxygenase-1 (HO-1) promoter and alcohol are related to the risk of esophageal squamous cell carcinoma on Chinese males |
| Author: J. L. HU, Z. Y. LI, W. LIU, R. G. ZHANG, G. L. LI, T. WANG, J. H. REN, G. WU |
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Abstract: Chronic alcohol drinking is a strong risk factor for esophageal squamous cell carcinoma (ESCC). In this study, the correlation between the HO-1 gene promoter polymorphism and alcohol, along with the risk of ESCC on Chinese males, was analyzed.The case-control study was performed in 143 ESCC patients and 264 cancer-free controls. All subjects were males. Allelotypic frequencies of (GT)n repeat were examed by PCR-based genotyping and DNA sequencing. The frequencies of L-allele and L-allele carriers (S/L and L/L genotypes) was significantly higher in ESCC patients than in controls (p = 0.001 and 0.004), The adjusted ORs for ESCC with S/L and L/L genotypes vs S/S genotype was 2.212 (95% CI 1.297-3.775, p = 0.004). The adjusted ORs for light, moderate and heavy drinking was 1.467, 5.215 and 9.525 respectively among L-allele carriers (S/L and L/L genotypes ) and 1.389, 2.096 and 3.039 respectively for the S/S genotype. Length of a (GT)n repeat in the HO-1 gene promoter may be associated with the development of ESCC in Chinese male drinkers. Reducing alcohol intake might be most protective among L-allele carriers of this polymorphism.
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| Keywords: esophageal squamous cell carcinoma; heme oxygenase-1 promoter polymorphism; alcohol drinking |
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| Year: 2010, Volume: 57, Issue: 1 |
Page From: 86, Page To: 92 |
doi:10.4149/neo_2010_01_086
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