Automated lung tumor segmentation for whole body PET volume based on novel downhill region growing

12 March 2010 Automated lung tumor segmentation for whole body PET volume based on novel downhill region growing

Cherry Ballangan, Xiuying Wang, Stefan Eberl, Michael Fulham, Dagan Feng

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 76233O (2010) https://doi.org/10.1117/12.844032
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

We propose an automated lung tumor segmentation method for whole body PET images based on a novel downhill region growing (DRG) technique, which regards homogeneous tumor hotspots as 3D monotonically decreasing functions. The method has three major steps: thoracic slice extraction with K-means clustering of the slice features; hotspot segmentation with DRG; and decision tree analysis based hotspot classification. To overcome the common problem of leakage into adjacent hotspots in automated lung tumor segmentation, DRG employs the tumors' SUV monotonicity features. DRG also uses gradient magnitude of tumors' SUV to improve tumor boundary definition. We used 14 PET volumes from patients with primary NSCLC for validation. The thoracic region extraction step achieved good and consistent results for all patients despite marked differences in size and shape of the lungs and the presence of large tumors. The DRG technique was able to avoid the problem of leakage into adjacent hotspots and produced a volumetric overlap fraction of 0.61 ± 0.13 which outperformed four other methods where the overlap fraction varied from 0.40 ± 0.24 to 0.59 ± 0.14. Of the 18 tumors in 14 NSCLC studies, 15 lesions were classified correctly, 2 were false negative and 15 were false positive.

Citation Download Citation

Cherry Ballangan, Xiuying Wang, Stefan Eberl, Michael Fulham, and Dagan Feng "Automated lung tumor segmentation for whole body PET volume based on novel downhill region growing", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76233O (12 March 2010); https://doi.org/10.1117/12.844032

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available