PEG/lecithin–liquid-crystalline composite hydrogels for quasi-zero-order combined release of hydrophilic and lipophilic drugs

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PEG/lecithin–liquid-crystalline composite hydrogels for quasi-zero-order combined release of hydrophilic and lipophilic drugs†

Hongbin Zhang,^a Rui Hao,^a Xiangkui Ren,^b Li Yu,^a Huai Yang*^a and Haifeng Yu*^a

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* Corresponding authors

^a Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing, P. R. China
E-mail: yuhaifeng@pku.edu.cn, yanghuai@coe.pku.edu.cn
Tel: +86-010-62764244

^b College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China

Abstract

Liquid crystalline microphase formed in PEG/lecithin hydrogels provides suppressed release of hydrophilic drugs but accelerated release for lipophilic drugs, achieving quasi-zero-order release of drugs with different water solubility.

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Article information

DOI: https://doi.org/10.1039/C3RA44080J
Article type: Communication
Submitted: 01 Aug 2013
Accepted: 07 Oct 2013
First published: 08 Oct 2013

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RSC Adv., 2013,3, 22927-22930

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