[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Integrated Visualization of Human Brain Connectome Data

  • Conference paper
  • First Online:
Brain Informatics and Health (BIH 2015)

Abstract

Visualization plays a vital role in the analysis of multi-modal neuroimaging data. A major challenge in neuroimaging visualization is how to integrate structural, functional and connectivity data to form a comprehensive visual context for data exploration, quality control, and hypothesis discovery. We develop a new integrated visualization solution for brain imaging data by combining scientific and information visualization techniques within the context of the same anatomic structure. New surface texture techniques are developed to map non-spatial attributes onto the brain surfaces from MRI scans. Two types of non-spatial information are represented: (1) time-series data from resting-state functional MRI measuring brain activation; (2) network properties derived from structural connectivity data for different groups of subjects, which may help guide the detection of differentiation features. Through visual exploration, this integrated solution can help identify brain regions with highly correlated functional activations as well as their activation patterns. Visual detection of differentiation features can also potentially discover image based phenotypic biomarkers for brain diseases.

S. Fang and L. Shen—This work was supported by NIH R01 LM011360, U01 AG024904, RC2 AG036535, R01 AG19771, P30 AG10133, and NSF IIS-1117335.

ADNI—Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 35.99
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
GBP 44.99
Price includes VAT (United Kingdom)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Behrens, T.E., Sporns, O.: Human connectomics. Curr. Opin. Neurobiol. 22(1), 144–153 (2012)

    Article  Google Scholar 

  2. Petrovic, V.: Visualizing whole-brain DTI tractography with GPU-based tuboids and LoD management. IEEE Trans. Vis. Comput. Graph. 13, 1488–1495 (2007)

    Article  Google Scholar 

  3. Stoll, C., et al.: Visualization with stylized line primitives. In: IEEE Vis., pp. 695–702 (2005)

    Google Scholar 

  4. Merhof, D.: Hybrid visualization for white matter tracts using triangle strips and point sprites. IEEE Trans. Vis. Comput. Graph. 12, 1181–1188 (2006)

    Article  Google Scholar 

  5. Peeters, T.H.J.M., et al.: Visualization of DTI fibers using hair-rendering techniques. Proc. ASCI, 66–73 (2006)

    Google Scholar 

  6. Parker, G.J.: A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements. J. Magn. Reson. Imaging 18, 242–254 (2003)

    Article  Google Scholar 

  7. von Kapri, A., et al.: Evaluating a visualization of uncertainty in probabilistic tractography. In: Proc. SPIE Medical Imaging Vis. Image-Guided Procedures and Modeling, p. 7625 (2010)

    Google Scholar 

  8. Achard, S.: A resilient, lowfrequency, small-world human brain functional network with highly connected association cortical hubs. J. Neurosci. 26, 63–72 (2006)

    Article  Google Scholar 

  9. Salvador, R.: Undirected graphs of frequency-dependent functional connectivity in whole brain networks. Philos. Trans. R. Soc. Lond. B Biol. Sci. 360, 937–946 (2005)

    Article  Google Scholar 

  10. Schwarz, A.J.: Negative edges and soft thresholding in complex network analysis of resting state functional connectivity data. NeuroImage 55, 1132–1146 (2011)

    Article  Google Scholar 

  11. van Horn, J.D.: Mapping connectivity damage in the case of Phineas Gage. PLoS One 7, e37454 (2012)

    Article  Google Scholar 

  12. Schurade, R., et al.: Visualizing white matter fiber tracts with optimally fitted curved dissection surfaces. In: EurographicsWorkshop on Vis. Comp. for Biol. and Med., pp. 41–48 (2010)

    Google Scholar 

  13. Eichelbaum, S.: LineAO improved threedimensional line rendering. IEEE Trans. Vis. Comput. Graph. 19, 433–445 (2013)

    Article  Google Scholar 

  14. Svetachov, P., et al.: DTI in context: illustrating brain fiber tracts in situ. In: EuroVis, pp. 1023–1032 (2010)

    Google Scholar 

  15. Hagmann, P., et al.: Mapping the structural core of human cerebral cortex. PLoS Biol 6(7) (2008)

    Google Scholar 

  16. Hagmann, P.: Mapping human whole-brain structural networks with diffusion MRI. PLoS One 2, 7 (2007)

    Article  Google Scholar 

  17. Cheng, H.: Optimization of seed density in dti tractography for structural networks. J. Neurosci. Methods 203(1), 264–272 (2012)

    Article  Google Scholar 

  18. Power, J.D.: Methods to detect, characterize, and remove motion artifact in resting state fMRI. Neuroimage 84, 320–341 (2014)

    Article  Google Scholar 

  19. Rubinov, M., Sporns, O.: Complex network measures of brain connectivity: uses and interpretations. Neuroimage 52(3), 1059–69 (2010)

    Article  Google Scholar 

  20. Biswal, B.B.: Resting state fMRI: A personal history. Neuroimage 62(2), 938–944 (2012)

    Article  Google Scholar 

  21. Rosenfeld, A.: Digital Picture Processing. Academic Press, New York (1982)

    Google Scholar 

  22. Nathan, G., Baoquan, C.: Paint inspired color mixing and compositing for visualization. In: IEEE Sym. on Info. Vis., pp. 113–118 (2004)

    Google Scholar 

  23. Liang, Y.D., et al.: Brain Connectome Visualization for Feature Classification. In: Proc. of IEEE Vis. (2014)

    Google Scholar 

  24. Perlin, K.: An image synthesizer. In: Proc. of SIGGRAPH, pp. 287–296 (1985)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Shiaofen Fang or Li Shen .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this paper

Cite this paper

Li, H. et al. (2015). Integrated Visualization of Human Brain Connectome Data. In: Guo, Y., Friston, K., Aldo, F., Hill, S., Peng, H. (eds) Brain Informatics and Health. BIH 2015. Lecture Notes in Computer Science(), vol 9250. Springer, Cham. https://doi.org/10.1007/978-3-319-23344-4_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-23344-4_29

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23343-7

  • Online ISBN: 978-3-319-23344-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics