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Towards an MP Model for B Lymphocytes Maturation

  • Conference paper
Unconventional Computation and Natural Computation (UCNC 2014)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 8553))

Abstract

A first dynamical model is given to explain maturation steps of B limphocytic cells in human body, based on Metabolic P systems with genetic regression of regulation maps. In humans, B cell development constitutes the steps that lead to B cell commitment and to expression of surface immunoglobulin, which is essential for B cell survival and function. Mature and fully functional B cells population (CD19+) include phenotypically and functionally different subgroups which persist during all stages of B-cell maturation. Quantities of eight different subgroups of B cells, identified by presence or absence of given receptors, were measured in about six thousands patients of all ages. Here we present a long work of preparation and analysis of (ex-vivo) data, and a preliminary model to explain the eight statistically refined time series, which opened up interesting questions about network inference and methodologies to analyze cross sectional data.

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Castellini, A., Franco, G., Manca, V., Ortolani, R., Vella, A. (2014). Towards an MP Model for B Lymphocytes Maturation. In: Ibarra, O., Kari, L., Kopecki, S. (eds) Unconventional Computation and Natural Computation. UCNC 2014. Lecture Notes in Computer Science(), vol 8553. Springer, Cham. https://doi.org/10.1007/978-3-319-08123-6_7

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  • DOI: https://doi.org/10.1007/978-3-319-08123-6_7

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08122-9

  • Online ISBN: 978-3-319-08123-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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